一种新型保湿霜减轻敏感性皮肤神经血管高反应性的临床观察
Clinical Observation of a Novel Moisturizing Cream for Reducing Neurovascular Hyper-Reactivity in Sensitive Skin.
作者信息
Jiang Li, Ouyang Jing, Wu Dian, Lai Miao, Yu Shuangli, Xu Zeheng, He Li
机构信息
Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Skin Health Research Center, Yunnan Characteristic Plant Extraction Laboratory, Kunming, China.
出版信息
J Cosmet Dermatol. 2025 Aug;24(8):e70287. doi: 10.1111/jocd.70287.
BACKGROUND
Sensitive skin is a syndrome characterized by unpleasant sensations in response to external stimuli. Its pathogenesis is linked to impaired skin barrier function, leading to neurovascular hyper-reactivity and inflammation. While topical functional skincare products are known to repair sensitive skin, there are limited reports on products specifically targeting the reduction of neurovascular hyper-reactivity.
OBJECTIVE
To evaluate the efficacy and safety of a novel cream in improving neurovascular hyper-reactivity and subjective symptoms in sensitive skin.
METHODS
This randomized, double-blind, self-controlled trial included 35 participants. One side of the face was treated with experimental cream (Group A) and the other with control cream (Group B), applied twice daily for 28 days. Follow-up assessments were performed on Day 0, Day 7, Day 14, and Day 28, with 28-day post-trial safety monitoring. Evaluations included clinical evaluation by physician, participant self-assessment of symptoms, measurements of skin physiological parameters and current perception threshold (CPT), lactic acid stinging test (LAST), capsaicin pain test (CAT), product usage experience, and participant tolerance.
RESULTS
The experimental cream demonstrates good safety and user experience. Both the experimental and control creams effectively improve symptoms and signs of sensitive skin, increase SC hydration, and lower TWEL, LAST, and DLQI scores. Additionally, the experimental cream outperforms the control cream in improving pruritus, erythema, and TWEL. The experimental cream also has the unique advantage of reducing CAT scores and increasing CPT.
CONCLUSION
The new cream has good safety and can effectively reduce neurovascular hyper-reactivity, alleviating symptoms in individuals with sensitive skin.
背景
敏感性皮肤是一种因对外部刺激产生不适感觉而表现出的综合征。其发病机制与皮肤屏障功能受损有关，进而导致神经血管反应过度和炎症。虽然已知局部功能性护肤品可修复敏感性皮肤，但专门针对降低神经血管反应过度的产品报道有限。
目的
评估一种新型乳膏改善敏感性皮肤神经血管反应过度和主观症状的疗效及安全性。
方法
本随机、双盲、自身对照试验纳入35名参与者。面部一侧使用试验乳膏（A组），另一侧使用对照乳膏（B组），每天涂抹两次，持续28天。在第0天、第7天、第14天和第28天进行随访评估，并在试验后进行28天的安全性监测。评估内容包括医生的临床评估、参与者对症状的自我评估、皮肤生理参数和电流感觉阈值（CPT）的测量、乳酸刺痛试验（LAST）、辣椒素疼痛试验（CAT）、产品使用体验以及参与者的耐受性。
结果
试验乳膏显示出良好的安全性和用户体验。试验乳膏和对照乳膏均能有效改善敏感性皮肤的症状和体征，增加皮肤角质层水合作用，并降低经皮水分流失（TWEL）、LAST和皮肤病生活质量指数（DLQI）评分。此外，试验乳膏在改善瘙痒、红斑和TWEL方面优于对照乳膏。试验乳膏还具有降低CAT评分和提高CPT的独特优势。
结论
这种新型乳膏具有良好的安全性，可有效降低神经血管反应过度，缓解敏感性皮肤个体的症状。
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