Alibabaei-Omran Fatemeh, Javanmehr Nima, Al-E-Ahmad Atiyeh, Zabihi Ebrahim, Najafi Tohid
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
J Tissue Eng Regen Med. 2025 Jul 23;2025:8818058. doi: 10.1155/term/8818058. eCollection 2025.
Regenerative medicine (RM) exploits stem cells to construct biological replacements and repair damaged tissues, offering an alternative to daunting organ transplantation. Even while RM has advanced quickly, building an entire organ remains beyond our capabilities. Experts are thus investigating the adoption of biologically generated composites that preserve the tissue's crucial physiological, morphological, and mechanical characteristics. Noncellular tissues like extracellular matrix offer cells a milieu similar to their physiological niche, becoming a promising substitute for synthetic composites. In this context, amnion, the membrane enclosing the fetus, is a great contender since it is widely obtainable and economical. Given its biochemical and anatomic characteristics, and the extensive supply of stem cells, growth factors, and matrix proteins, the amnion is considered a fantastic candidate to employ in RM. Decellularized amniotic membrane (DAM) has many uses as two- and three-dimensional scaffolds, anchoring for cell adhesion and expansion for tissue regeneration, and as carrier systems for cell and drug cargoes. The present research aims to assess the recent surge in DAM-RM research, potentially to get beyond the existing barriers impeding the RM's clinical translation landscape. The present paper draws a comprehensive picture of the experimental evidence and clinical trials regarding exploiting DAM in RM.
再生医学（RM）利用干细胞构建生物替代物并修复受损组织，为令人生畏的器官移植提供了一种替代方案。尽管RM发展迅速，但构建整个器官仍超出我们的能力范围。因此，专家们正在研究采用能保留组织关键生理、形态和机械特性的生物生成复合材料。像细胞外基质这样的无细胞组织为细胞提供了类似于其生理微环境的环境，成为合成复合材料的一个有前途的替代品。在这种背景下，羊膜，即包裹胎儿的膜，是一个有力的竞争者，因为它易于获取且经济实惠。鉴于其生化和解剖学特性，以及干细胞、生长因子和基质蛋白的丰富供应，羊膜被认为是RM中一个非常理想的应用候选物。脱细胞羊膜（DAM）作为二维和三维支架有多种用途，可用于细胞黏附的锚定和组织再生的细胞扩增，还可作为细胞和药物载体系统。本研究旨在评估DAM-RM研究最近的激增情况，有可能突破阻碍RM临床转化前景的现有障碍。本文全面描绘了关于在RM中利用DAM的实验证据和临床试验情况。
