Xu Chenggang, Shen Yu, Zhang Lina, Wang Feng, Xiang Shuting
Department of Cardiology, XuanCheng City Central Hospital, Xuancheng, China.
Department of Pharmacology, Anhui Medical University, Hefei, China.
Mediators Inflamm. 2025 Jul 23;2025:4123997. doi: 10.1155/mi/4123997. eCollection 2025.
Dehydroandrographolide (Deh) is one of the main active ingredients of the traditional Chinese medicine . In recent years, its pharmacological research has made remarkable progress in the fields of antibacterial, anti-inflammatory, antitumor, and antiviral therapies. As a traditional herbal medicine, has long been used in the clinical treatment of infectious diseases, immune disorders, and liver injury. Deh, the plant's core active molecule, has demonstrated therapeutic potential beyond that of its source, owing to its distinctive chemical structure and multitarget mechanism of action. Studies have shown that Deh not only inhibits inflammatory responses by regulating NF-κB, Nrf2, and other related pathways but also induces apoptosis and cycle blockade in tumor cells and exerts antiviral effects by interfering with the viral replication cycle. In this review, we systematically summarized the diverse pharmacological activities of Deh and its molecular mechanisms, drawing attention to its potential role in the treatment of inflammation-related diseases. We hope this work will serve as a theoretical reference for designing innovative drugs based on natural products and encourage the clinical translation of 's active ingredients.
去氢穿心莲内酯（Deh）是中药的主要活性成分之一。近年来，其药理学研究在抗菌、抗炎、抗肿瘤和抗病毒治疗领域取得了显著进展。作为一种传统草药，长期以来一直用于传染病、免疫紊乱和肝损伤的临床治疗。Deh作为该植物的核心活性分子，由于其独特的化学结构和多靶点作用机制，已显示出超越其来源的治疗潜力。研究表明，Deh不仅通过调节NF-κB、Nrf2等相关途径抑制炎症反应，还能诱导肿瘤细胞凋亡和细胞周期阻滞，并通过干扰病毒复制周期发挥抗病毒作用。在本综述中，我们系统地总结了Deh的多种药理活性及其分子机制，提请关注其在治疗炎症相关疾病中的潜在作用。我们希望这项工作将为基于天然产物设计创新药物提供理论参考，并促进该植物活性成分的临床转化。
