Kiriyama Yoshimitsu, Nakatsuma Akira, Tokumaru Hiroshi, Sadamoto Hisayo, Nochi Hiromi
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Takamatsu 769-2193, Kagawa, Japan.
Institute of Neuroscience, Tokushima Bunri University, Takamatsu 769-2193, Kagawa, Japan.
Biochem Res Int. 2025 Jul 24;2025:4849733. doi: 10.1155/bri/4849733. eCollection 2025.
Nuclear receptor subfamily 4 group A member 1 (NR4A1), which is also known as nuclear receptor 77 (NUR77), NGFI-B, or testicular receptor 3 (TR3), is a member of the NR4A subfamily of the nuclear receptor superfamily. NR4A1 has both nuclear localization and nuclear export signals, and NR4A1 is present in the cytoplasm as well as the nucleus. NR4A1 alters its subcellular localization through phosphorylation or SUMOylation. In the nucleus, NR4A1 plays an important role in regulating gene expression by directly binding to genomic DNA or indirectly influencing other transcription factors. In the cytoplasm, NR4A1 affects the stabilization of β-catenin, which is involved in various tumorigenesis. Furthermore, NR4A1 is involved in LPS-induced inflammasome activation. In mitochondria and endoplasmic reticulum, NR4A1 plays an important role in the induction of autophagy and apoptosis. In this review, we focused on the current knowledge of subcellular localization and molecular function of NR4A1.
核受体亚家族4 A组成员1（NR4A1），也被称为核受体77（NUR77）、NGFI - B或睾丸受体3（TR3），是核受体超家族NR4A亚家族的成员。NR4A1同时具有核定位信号和核输出信号，并且在细胞质和细胞核中均有存在。NR4A1通过磷酸化或SUMO化作用改变其亚细胞定位。在细胞核中，NR4A1通过直接结合基因组DNA或间接影响其他转录因子，在调节基因表达方面发挥重要作用。在细胞质中，NR4A1影响β-连环蛋白的稳定性，而β-连环蛋白参与多种肿瘤发生过程。此外，NR4A1参与脂多糖诱导的炎性小体激活。在线粒体和内质网中，NR4A1在自噬和凋亡的诱导中发挥重要作用。在本综述中，我们重点关注了NR4A1亚细胞定位和分子功能的当前知识。
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