Li Yang, Wang Bin, Luo Xiangdong, Zhang Mingqin, Hu Qinrui, Li Xiaoxin
School of Medicine, Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen University, Xiamen, China.
Xiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, China.
Sci Rep. 2025 Aug 1;15(1):28174. doi: 10.1038/s41598-025-12717-w.
The aim of this study was to determine the prevalence, associations and ROC prediction of vitreoretinal interface disorders (VRI) among residents aged 50 years and older in Fujian Eye Study.The Fujian Eye Study is a population-based cross-sectional eye study in Fujian province, Southeast China. Residents aged 50 years and older were enrolled and did the questionnaire, physical and ophthalmological examinations. Multicolor OCT was used for high-resolution imaging of central retina in both eyes. Stata/SE 15.1 software was used for statistic analysis, a multivariate logistic regression model was used to identify associated factors for high myopia and the ROC curve analysis was used to verify the credibility.A total of 8173 residents were finally included in this study. The prevalence of VRI was 8.99% (95%CI: 8.37-9.61%), including 93.61% (95%CI: 91.84-95.37%) with ERM, 14.56% (95%CI: 12.01-17.11%) with any type of macular hole (MH) in at least one eye, and 2.45% (95%CI: 1.33-3.57%) with vitreoretinal traction (VRT). ERM was the most common type of VRI. Multiple logistic regression showed urban residency and coastal location were independently associated with VRI.The prevalence of VRI was high among Chinese adults, and ERM was the most common type of VRI. VRI was associated with urban residency and coastal location. This study provided the population-based data on the prevalence of VRI disorders in the Chinese elderly and filled in the global data.
本研究旨在确定福建眼科研究中50岁及以上居民玻璃视网膜界面疾病（VRI）的患病率、相关因素及ROC预测。福建眼科研究是一项基于人群的横断面眼科研究，在中国东南部的福建省开展。纳入50岁及以上居民并进行问卷调查、体格检查和眼科检查。使用多色OCT对双眼中央视网膜进行高分辨率成像。采用Stata/SE 15.1软件进行统计分析，使用多变量逻辑回归模型识别高度近视的相关因素，并采用ROC曲线分析验证可信度。本研究最终共纳入8173名居民。VRI的患病率为8.99%（95%CI：8.37-9.61%），其中视网膜前膜（ERM）占93.61%（95%CI：91.84-95.37%），至少一只眼有任何类型黄斑裂孔（MH）的占14.56%（95%CI：12.01-17.11%），玻璃体视网膜牵拉（VRT）占2.45%（95%CI：1.33-3.57%）。ERM是VRI最常见的类型。多因素逻辑回归显示，城市居住和沿海地区与VRI独立相关。中国成年人中VRI的患病率较高，且ERM是VRI最常见的类型。VRI与城市居住和沿海地区有关。本研究提供了中国老年人VRI疾病患病率的基于人群的数据，填补了全球数据空白。
