Szpak Veronica, Carc Andrea Velez, Prostko Sara, Rosenblum Naomi, Maurer Rie, Aguiar Lyndon J, Weiss Roger D, Suzuki Joji
Department of Psychiatry, Brigham and Women's Hospital, 60 Fenwood Rd, Boston, MA, 02115, USA.
Harvard Catalyst, Boston,, MA, USA.
Addict Sci Clin Pract. 2025 Aug 1;20(1):61. doi: 10.1186/s13722-025-00589-4.
Individuals with opioid use disorder (OUD) are frequently hospitalized for injection-related medical complications, yet they often receive inadequate treatment for the OUD itself. We previously conducted a qualitative study to adapt an existing remotely delivered intensive outpatient program (IOP) specifically for hospitalized patients with OUD. We then conducted a pilot feasibility and acceptability study to assess the program.
The 4-week IOP consisted of asynchronous video content and in-person peer support. The primary outcomes were the feasibility of recruitment, acceptability of the treatment as assessed by the completion of videos, and engagement with the peer recovery coach. Secondary outcomes included OUD treatment retention.
Of the 12 participants, the mean age was 40.9 years, 58.3% were female, and 58.3% had an injection-related serious infection. Results demonstrated potentially acceptable recruitment feasibility (70.6%, 95% CI [48.9-92.3]), but the median percentage of video completion was only 2% (range: 0-16%) and the median percentage of engagement with recovery coach was 31.8% (range: 16.7-66.7%). All participants received medications for OUD (MOUD) during the hospital stay (methadone 83%, buprenorphine 17%), and 33.3% remained retained in MOUD treatment at 28 days.
Hospitalized patients with OUD desired additional support through an IOP along with MOUD. While recruitment feasibility was acceptable, the overall program was not. Future research should explore IOP content that is more personalized and engaging while also including peer support.
患有阿片类物质使用障碍（OUD）的个体经常因注射相关的医疗并发症而住院，但他们对OUD本身的治疗往往不足。我们之前进行了一项定性研究，以改编现有的远程提供的强化门诊项目（IOP），专门针对住院的OUD患者。然后我们进行了一项试点可行性和可接受性研究来评估该项目。
为期4周的IOP包括异步视频内容和面对面的同伴支持。主要结局是招募的可行性、通过视频完成情况评估的治疗可接受性以及与同伴康复教练的互动。次要结局包括OUD治疗的持续性。
12名参与者的平均年龄为40.9岁，58.3%为女性，58.3%患有与注射相关的严重感染。结果显示招募可行性可能是可接受的（70.6%，95%CI[48.9 - 92.3]），但视频完成的中位数百分比仅为2%（范围：0 - 16%），与康复教练互动的中位数百分比为31.8%（范围：16.7 - 66.7%）。所有参与者在住院期间都接受了阿片类物质使用障碍药物治疗（MOUD）（美沙酮83%，丁丙诺啡17%），28天时33.3%仍在接受MOUD治疗。
住院的OUD患者希望通过IOP以及MOUD获得额外支持。虽然招募可行性是可接受的，但整个项目并非如此。未来的研究应探索更个性化、更具吸引力且包含同伴支持的IOP内容。
