Expansion of receptive fields in the mouse cortical barrelfield after administration of capsaicin to neonates or local application on the infraorbital nerve in adults.

A possible role fore peripheral unmyelinated fibres on the establishment and maintenance of stable receptive fields mediated by myelinated afferents has been studied in the mouse cortical barrelfield. The barrels are cytoarchitectonic units consituting a visible and particularly precise somatotopic map of the facial vibrissae. Barrelfields were mapped electrophysiologically in adults using two experimental setups: (i) after destruction of unmyelinated peripheral fibres by systemic administration of capsaicin neonatally; and (ii) after inactivation of these fibres by local application of capsaicin to the nerve subserving the vibrissae in the adult. The latter procedure is known not to destroy fibres. Control animals received the vehicle used to dissolve capsaicin. The effectiveness of capsaicin on the peripheral fibres was assessed histochemically on their terminals in the substantia gelatinosa. Both methods of application of capsaicin resulted in a large expansion of cortical receptive fields: units within a particular barrel were driven by a statistically significant, larger number of vibrissae than in controls. No morphological alterations of the barrels were found in cortical tangential sections. We concluded that capsaicin treatment 'defocusses' the normal physiological precision without destroying the general plan of representation and without alteration of the barrel pattern.