Suppr超能文献

病例报告:乳腺癌患者经外周静脉穿刺中心静脉导管(PICC)-输液港发生多柔比星外渗的成功多学科处理方法。

Case Report: A successful multidisciplinary approach to doxorubicin extravasation from a PICC-port in a patient with breast cancer.

作者信息

Calabrò Concetta, Iacovelli Serena, De Palma Giuseppe, Carravetta Giuseppe, Garofalo Domenica, Giotta Francesco, Latorre Agnese, Nardulli Patrizia, Ressa Cosmo Maurizio, Vitale Elsa, De Santis Valerio, Mastrandrea Giovanni

机构信息

Pharmacy Unit, IRCCS Istituto Tumori "Giovanni Paolo II" Bari, Bari, Italy.

Institutional BioBank, Experimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori "Giovanni Paolo II" Bari, Bari, Italy.

出版信息

Front Oncol. 2025 Jul 18;15:1534112. doi: 10.3389/fonc.2025.1534112. eCollection 2025.

Abstract

BACKGROUND

Infusion of chemotherapy drugs through central venous catheters in the bloodstream facilitates direct access to disseminated cancer sites to interrupt the growth and/or spread of abnormal cells. To represent the significance of a rapid, multidisciplinary intervention codified by a hospital-adopted procedure for the treatment of this specific type of extravasation.

METHODS

A case of a 63-year-old female patient with no comorbidities but overweight who was admitted to our hospital in 2023 was discussed. The oncologist requested the placement of a long-term central venous access for chemotherapy, expected to last at least 5-6 months. This case report describes a massive anthracycline extravasation through a PICC-port. Such a serious complication requires not only the prompt administration of dexrazoxane but, more importantly, a multidisciplinary approach. Without comprehensive and timely intervention, the patient would have likely lost the upper limb.

CLINICAL IMPLICATIONS

Following the surgical and pharmacological treatment, the patient achieved a restoration of normal limb function, thus resuming all regular activities. This outcome was made possible primarily due to the timely and professional intervention of the multidisciplinary team, which minimized the severe complications that doxorubicin extravasation can cause. Tunneling of the catheter, which moves the extravasation site (port pocket) away from the venipuncture site, is equally important. Another noteworthy element is the resumption of chemotherapy treatment, which might have been interrupted due to the severe complication resulting from the extravasation.

摘要

背景

通过中心静脉导管将化疗药物注入血流,有助于直接到达扩散的癌症部位,以阻断异常细胞的生长和/或扩散。为了体现医院采用的程序所规定的快速多学科干预对于治疗这种特定类型外渗的重要性。

方法

讨论了一例2023年入住我院的63岁女性患者,该患者无合并症但超重。肿瘤学家要求放置长期中心静脉通路用于化疗,预计持续至少5 - 6个月。本病例报告描述了通过经外周静脉穿刺中心静脉导管(PICC)-端口发生的大量蒽环类药物外渗。如此严重的并发症不仅需要迅速给予右丙亚胺,更重要的是需要多学科方法。如果没有全面及时的干预,患者很可能会失去上肢。

临床意义

经过手术和药物治疗后,患者肢体功能恢复正常,从而恢复了所有日常活动。这一结果主要得益于多学科团队及时专业的干预,将阿霉素外渗可能导致的严重并发症降至最低。导管隧道化将外渗部位(端口袋)与静脉穿刺部位分开同样重要。另一个值得注意的因素是化疗治疗的恢复,化疗可能因外渗导致的严重并发症而中断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fbc/12313700/b86b9a6fe41a/fonc-15-1534112-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验