Wang Olivia, Mei Li, Polonowita Ajith, Guan Guangzhao
Department of Oral Diagnostic and Surgical Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Department of Oral Sciences, University of Otago, Dunedin, New Zealand.
J R Soc N Z. 2024 Oct 1;55(6):1384-1399. doi: 10.1080/03036758.2024.2406818. eCollection 2025.
Burning Mouth Syndrome (BMS) presents as a persistent, often perplexing pain condition characterised primarily by a sensation of burning, yet frequently lacks observable clinical evidence. The underlying mechanisms of BMS remain elusive. Typically, the tongue bears the brunt of the discomfort, followed by the inner lower lip and hard palate. Psychologically, BMS often intersects with anxiety and depression, forming common comorbidities. There's emerging research suggesting a potential link between Human Herpesvirus 6B (HHV-6B) and mental health disorders. This association raises the possibility of HHV-6B as a contributor to BMS. HHV-6B's hypothesised involvement in BMS could be from various avenues: direct damage to taste cells and nerves, eliciting an inflammatory response, or even disrupting olfactory functions. This narrative review aims to critically evaluate the current literature on the potential association between HHV-6B and BMS. It explores the role of HHV-6B in pain mechanisms, inflammatory responses, and its impact on sensory functions such as taste and olfaction, providing a comprehensive overview of its implications in BMS pathogenesis.
灼口综合征（BMS）表现为一种持续存在且常常令人困惑的疼痛状况，其主要特征为灼烧感，但通常缺乏可观察到的临床证据。BMS的潜在机制仍然不明。通常，舌头首当其冲地承受不适，其次是下唇内侧和硬腭。在心理方面，BMS常与焦虑和抑郁交织，形成常见的共病情况。有新出现的研究表明，人疱疹病毒6B（HHV-6B）与精神健康障碍之间可能存在联系。这种关联增加了HHV-6B导致BMS的可能性。HHV-6B被推测参与BMS的途径可能有多种：对味觉细胞和神经的直接损伤、引发炎症反应，甚至扰乱嗅觉功能。这篇叙述性综述旨在批判性地评估当前关于HHV-6B与BMS潜在关联的文献。它探讨了HHV-6B在疼痛机制、炎症反应中的作用，以及其对味觉和嗅觉等感觉功能的影响，全面概述了其在BMS发病机制中的意义。
