Färdig Martin, Lingman Karin, Lisspers Karin, Ställberg Björn, Janson Christer, Högman Marieann, Malinovschi Andrei
Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
These authors contributed equally.
ERJ Open Res. 2025 Aug 4;11(4). doi: 10.1183/23120541.01078-2024. eCollection 2025 Jul.
While oscillometry appears advantageous over spirometry in detecting peripheral airway dysfunction, a feature of COPD, further research on its role in disease monitoring is needed. The objectives of the present study were to analyse the associations between oscillometry by impulse oscillometry (IOS) and forced oscillation technique (FOT) and airway obstruction, health status, dyspnoea and future exacerbations in COPD.
Oscillometry and disease burden were assessed in 150 adults with COPD within the Tools Identifying Exacerbations study. At 5 Hz, abnormal resistance ( ) and reactance ( ) were defined as -scores >1.645 and <-1.645 sd, respectively, whereas a mean difference in reactance between inspiration and expiration >2.80 cmHO·L·s represented abnormal Δ . Forced expiratory volume in 1 s (FEV), COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) scores were obtained. Medical records were reviewed for future exacerbations (≥1) between baseline and 1 and 3 years, respectively.
Abnormal oscillometry correlated with disease burden, with the highest risk observed for severe airway obstruction (FEV <50% pred): odds ratios with 95% confidence intervals ranging from 4.80 (1.93-12.0) to 18.0 (7.13-45.3) for , and Δ , followed by moderate to severe dyspnoea (mMRC ≥2) for Δ , COPD health status (CAT ≥10) for and Δ and future exacerbations (1 and 3 years) for and , respectively, with odds ratios (95% CI) ranging from 2.77 (1.27-6.05) to 3.98 (1.38-11.5).
Abnormal oscillometry may be relevant in the evaluation of COPD patients, including the prediction of future exacerbation risk.
虽然在检测慢性阻塞性肺疾病（COPD）的外周气道功能障碍这一特征方面，振荡法似乎比肺量计法更具优势，但仍需进一步研究其在疾病监测中的作用。本研究的目的是分析脉冲振荡法（IOS）和强迫振荡技术（FOT）进行的振荡法与COPD患者的气道阻塞、健康状况、呼吸困难及未来急性加重之间的关联。
在“识别急性加重的工具”研究中，对150例成年COPD患者进行了振荡法和疾病负担评估。在5Hz时，异常阻力（ ）和电抗（ ）分别定义为z分数>1.645和<-1.645标准差，而吸气与呼气之间电抗的平均差值>2.80cmH₂O·L⁻¹·s表示异常ΔX。获取第1秒用力呼气量（FEV₁）、COPD评估测试（CAT）和改良医学研究委员会（mMRC）评分。回顾病历以了解基线与1年及3年之间未来的急性加重情况（≥1次）。
异常振荡法与疾病负担相关，在严重气道阻塞（FEV₁<50%预计值）时观察到的风险最高：对于 、 和ΔX，比值比及其95%置信区间范围为4.80（从1.93至12.0）至18.0（从7.13至45.3），其次，对于ΔX是中度至重度呼吸困难（mMRC≥2），对于 和ΔX是COPD健康状况（CAT≥10），对于 和 分别是未来急性加重（1年和3年），比值比（95%CI）范围为2.77（从1.27至6.05）至3.98（从1.38至11.5）。
异常振荡法可能在COPD患者评估中具有相关性，包括对未来急性加重风险的预测。
