Wei Zhongcao, Zhang Yu, Xu Shaoxian, Tong Mei, Yang Xing, Xing Xin, Dai Fei, Wang Jinhai, Qin Bin
Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi'an, China.
Front Public Health. 2025 Jul 21;13:1592358. doi: 10.3389/fpubh.2025.1592358. eCollection 2025.
No study has assessed the relationship between separation factors and irritable bowel syndrome (IBS). We assess the association between the separation factors and IBS in Chinese left-behind children (LBC).
In this school-based study, we analyzed data from eight representative primary and secondary schools to assess the association between separation factors and IBS in Chinese LBC based on the Rome IV criteria. While individual-level income data were unavailable, all analyses were adjusted for regional socioeconomic disparities (Guanzhong Basin vs. Northern Shaanxi vs. Southern Shaanxi).
A total of 349 IBS and 7,355 non-IBS children were included, and the proportion of LBC was 21.13%. Univariate analysis showed statistically significant differences in separation status between IBS and non-IBS children ( < 0.05). Multivariate analysis showed that in the model adjusted for demographic variables, separation from both parents demonstrated the strongest association with IBS (OR = 2.2, < 0.0001), and separation from father only (OR = 2.1, < 0.0001) was significantly positively associated with IBS, but separation from mother only was not significantly associated with IBS ( > 0.05), and the same trend was observed in the subgroup analysis of sex. The relationship between age and IBS risk in LBC was nonlinear, and the risk of IBS in LBC was highest at age 8 years.
Separation from father only was significantly positively associated with IBS. And the relationship between age and IBS risk in LBC was nonlinear.
尚无研究评估分离因素与肠易激综合征（IBS）之间的关系。我们评估中国留守儿童（LBC）中分离因素与IBS之间的关联。
在这项基于学校的研究中，我们分析了来自八所具有代表性的中小学的数据，以根据罗马IV标准评估中国留守儿童中分离因素与IBS之间的关联。虽然无法获得个人层面的收入数据，但所有分析均针对区域社会经济差异（关中盆地与陕北与陕南）进行了调整。
共纳入349例IBS儿童和7355例非IBS儿童，留守儿童比例为21.13%。单因素分析显示，IBS儿童与非IBS儿童在分离状态上存在统计学显著差异（P<0.05）。多因素分析显示，在调整了人口统计学变量的模型中，与父母双方分离与IBS的关联最强（OR=2.2，P<0.0001），仅与父亲分离（OR=2.1，P<0.0001）与IBS显著正相关，但仅与母亲分离与IBS无显著关联（P>0.05），在性别亚组分析中也观察到相同趋势。留守儿童的年龄与IBS风险之间的关系是非线性的，8岁时留守儿童患IBS的风险最高。
仅与父亲分离与IBS显著正相关。且留守儿童的年龄与IBS风险之间的关系是非线性的。
