Parthasarathy B, K Kirubhakaran, Selvam S Pravin
Department of General Medicine, Vinayaka Mission's Kirupananda Variyar Medical College and Hospitals (VMKVMCH), Vinayaka Mission's Research Foundation (DU), F Block Room No. 7 PG Boys Hostel, Chinnaseragapadi, Salem, Tamilnadu, 636308, India.
Ir J Med Sci. 2025 Aug 6. doi: 10.1007/s11845-025-04050-y.
Diabetes mellitus is a growing global health concern, with an estimated 643 million individuals projected to be affected by 2030. Sarcopenia, once considered a normal part of aging, is now known to be associated with chronic diseases, including type 2 diabetes mellitus (T2DM). Muscle mass typically declines by approximately 8% per decade after age 40, accelerating to 15-25% per decade after age 70.
To determine the prevalence of sarcopenia in patients with T2DM of more than 10 years' duration and evaluate its association with bone mineral density (BMD).
An observational study was conducted at a tertiary care hospital in Salem from January to October 2024. A total of 120 patients with T2DM for over 10 years were included. Data collected included demographics, medical history (fractures, comorbidities, use of insulin, bisphosphonates, or vitamin D supplements), and physical examination findings (weight, height, BMI, and blood pressure). Sarcopenia and BMD were assessed using dual-energy X-ray absorptiometry (DEXA).
The mean age of participants was 63.4 ± 8.7 years. Most had diabetes for 10-15 years (56.7%), and 32.5% had 16-20 years. The mean BMI was 25.7 ± 3.4 kg/m. Sarcopenia was present in 30.0% of participants. Additionally, 48.3% had osteopenia and 28.3% had osteoporosis.
Routine screening for sarcopenia and BMD in older adults with long-standing T2DM is essential for early intervention. Good glycemic control may help mitigate the risk of sarcopenia and related complications.
糖尿病是一个日益引起全球健康关注的问题，预计到2030年将有6.43亿人受到影响。肌肉减少症曾被认为是衰老的正常组成部分，现在已知与包括2型糖尿病（T2DM）在内的慢性疾病有关。40岁以后，肌肉量通常每十年下降约8%，70岁以后加速至每十年下降15%-25%。
确定病程超过10年的T2DM患者中肌肉减少症的患病率，并评估其与骨密度（BMD）的关系。
2024年1月至10月在塞勒姆的一家三级护理医院进行了一项观察性研究。共纳入120例病程超过10年的T2DM患者。收集的数据包括人口统计学、病史（骨折、合并症、胰岛素、双膦酸盐或维生素D补充剂的使用情况）以及体格检查结果（体重、身高、BMI和血压）。使用双能X线吸收法（DEXA）评估肌肉减少症和BMD。
参与者的平均年龄为63.4±8.7岁。大多数人患糖尿病10-15年（56.7%），32.5%的人患糖尿病16-20年。平均BMI为25.7±３.4kg/m。30.0%的参与者存在肌肉减少症。此外，48.3%的人患有骨质减少症，28.3%的人患有骨质疏松症。
对长期患T2DM的老年人进行肌肉减少症和BMD的常规筛查对于早期干预至关重要。良好的血糖控制可能有助于降低肌肉减少症及相关并发症的风险。
