Development. 2025 Aug 1;152(15). doi: 10.1242/dev.205120. Epub 2025 Aug 7.
Pyruvate dehydrogenase E1 subunit alpha 2 (PDHA2) is a testis-specific mitochondrial protein involved in energy metabolism and spermatogenesis. In their study, Keisuke Shimada and colleagues show that PDHA2 is crucial for normal spermatogenesis and it likely compensates for Pdha1, which is normally silenced during meiosis, in male germ cells. To find out more about their work, we spoke to the first author, Chen Pan, and the corresponding author, Keisuke Shimada, Associate Professor at the Laboratory of Disease Models, School of Veterinary Medicine, Rakuno Gakuen University, Japan.
丙酮酸脱氢酶E1α亚基2(PDHA2)是一种睾丸特异性线粒体蛋白,参与能量代谢和精子发生。在他们的研究中,岛田圭介及其同事表明,PDHA2对正常精子发生至关重要,并且它可能在雄性生殖细胞中补偿了在减数分裂期间通常沉默的Pdha1。为了进一步了解他们的工作,我们采访了第一作者陈盼以及通讯作者岛田圭介,他是日本酪农学园大学兽医学院疾病模型实验室的副教授。