体外使用消炎痛增强获得性免疫缺陷综合征及艾滋病相关综合征患者有丝分裂原诱导的增殖反应。

Augmentation of mitogen-induced proliferative responses by in vitro indomethacin in patients with acquired immune deficiency syndrome and AIDS-related complex.

作者信息

Reddy M M, Manvar D, Ahuja K K, Moriarty M L, Grieco M H

出版信息

Int J Immunopharmacol. 1985;7(6):917-21. doi: 10.1016/0192-0561(85)90055-4.

Abstract

The effect of indomethacin on mitogen-induced lymphocyte proliferative responses was studied in six normal heterosexual subjects and nine patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC). Indomethacin enhanced only Con A-induced lymphocyte responses in six heterosexual men. In contrast, study of the cells from AIDS and ARC revealed that indomethacin enhanced PHA-induced lymphocyte proliferative responses from 52,600 counts/min to 70,900 counts/min (P less than 0.005) and 81,400 counts/min (P less than 0.001) at 0.1 and 1 microgram/ml. respectively and increased Con A-induced lymphoproliferation from 30,800 counts/min to 52,000 counts/min (P less than 0.01) at 0.1 microgram/mg and 51,1000 counts/min (P less than 0.005) at 1 microgram/ml. These results suggest that indomethacin enhanced mitogen-induced lymphoproliferative responses in vitro with cells from patients with AIDS and AIDS-related complex and may have therapeutic potential in some patients with AIDS.

摘要

在6名正常异性恋受试者以及9名获得性免疫缺陷综合征（AIDS）和艾滋病相关综合征（ARC）患者中，研究了吲哚美辛对有丝分裂原诱导的淋巴细胞增殖反应的影响。吲哚美辛仅增强了6名异性恋男性中由刀豆蛋白A诱导的淋巴细胞反应。相比之下，对艾滋病和艾滋病相关综合征患者细胞的研究显示，在0.1微克/毫升和1微克/毫升时，吲哚美辛分别将由植物血凝素诱导的淋巴细胞增殖反应从52,600计数/分钟提高到70,900计数/分钟（P<0.005）和81,400计数/分钟（P<0.001），并在0.1微克/毫克时将由刀豆蛋白A诱导的淋巴细胞增殖从30,800计数/分钟提高到52,000计数/分钟（P<0.01），在1微克/毫升时提高到51,100计数/分钟（P<0.005）。这些结果表明，吲哚美辛在体外增强了艾滋病和艾滋病相关综合征患者细胞对有丝分裂原诱导的淋巴细胞增殖反应，并且可能对一些艾滋病患者具有治疗潜力。