BACKGROUND

Hypothyroidism is a common chronic disease that can substantially impair physical and mental well-being and is associated with lower quality of life, a trend that interventions delivered by mobile health (mHealth) apps could ameliorate.

OBJECTIVE

The objective of this study was to evaluate the acceptance and its influencing predictors of mHealth interventions in female patients affected by hypothyroidism to improve their quality of life. The focus on female patients reflects the significantly higher prevalence of hypothyroidism in women and their underrepresentation in many prior studies on technology acceptance and mHealth use.

METHODS

A survey-based, cross-sectional study, which included 318 female patients affected by hypothyroidism (assessed via self-reported diagnosis according to International Classification of Diseases-10 criteria, aged 18 y or older), was conducted online between April 2023 and April 2024 in Germany. Participants were recruited via local and online self-help groups, social media platforms, and medical practices using flyers. Sociodemographic, health, and eHealth-related data were assessed. To determine acceptance and its drivers and barriers, an extended version of the unified theory of acceptance and use of technology (UTAUT) model was applied. Group comparisons (t tests, ANOVAs) and multiple hierarchical regression analyses were conducted. Only complete datasets were included in the analysis.

RESULTS

Acceptance of mHealth apps was high (mean 4.10, SD 0.91), with 76.1% (n=242) of the participants reporting high acceptance, 18.6% (n=59) reporting moderate acceptance, and only 5.3% (n=17) reporting low acceptance. Significant predictors of acceptance were place of residence: medium-sized city (β=0.34; P=.02) and small town or rural area (β=0.28; P=.003), fatigue (β=0.54; P<.001), internet anxiety (β=-0.20; P=.002), and the UTAUT predictors effort expectancy (β=0.37; P<.001), performance expectancy (β=0.32; P<.001), and social influence (β=0.20; P<.001). The extended model explained 56.1% of the variance in acceptance.

CONCLUSIONS

The high level of acceptance of mHealth apps observed among female patients affected by hypothyroidism indicates that mHealth interventions can provide such patients with valuable support to manage the disease and improve their quality of life. Addressing drivers and barriers of acceptance will be crucial for the successful implementation of mHealth interventions in hypothyroidism management, for example, by mHealth developers, clinicians, or policy makers. These include intuitive and accessible design (effort expectancy), clear communication of app benefits (performance expectancy), and fostering health care professional support (social influence), while addressing barriers such as internet anxiety. The study also contributes to advancing gender-sensitive mHealth research by applying the UTAUT model to this patient group.