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使用抗精神病药物的精神障碍患者的代谢监测:一项旨在解决这一具有挑战性的指南与实践差距的质量改进项目的结果

Metabolic monitoring among patients with psychotic disorders taking antipsychotics: results of a quality improvement project to address this challenging guideline-practice gap.

作者信息

Al-Saati Yomen, Vijayakumar Ethiraj, Khan Eefa, Leong Christine, Hensel Jennifer, Kuzenko Nina

机构信息

Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada.

College of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.

出版信息

BMJ Open Qual. 2025 Aug 6;14(3):e003400. doi: 10.1136/bmjoq-2025-003400.

Abstract

BACKGROUND

Metabolic adverse effects of antipsychotic medications pose significant health risks for patients with psychotic disorders. Despite clinical practice guidelines recommending regular metabolic monitoring, adherence to these recommendations remains suboptimal in psychiatric settings.

OBJECTIVE

This quality improvement project aimed to assess the impact of an organisational paper-based metabolic monitoring form (MMF) on monitoring practices for patients with psychotic disorders receiving antipsychotic medications at an outpatient psychiatric clinic in a large Canadian city.

METHODS

A pre-post intervention study was carried out to assess the impact of the MMF on annual monitoring among 75 randomly selected eligible patients. Metabolic monitoring parameters (blood pressure, weight, waist circumference and glucose and lipid profiles) were reviewed 1 year before and after the introduction of the form.

RESULTS

The MMF was missing from 10 charts, and despite its presence in the remainder, no improvement was observed in metabolic parameter documentation, and overall guideline adherence remained low. Fasting glucose and HbA1c measurements were most frequently ordered, while blood pressure and weight measurements remained consistently low across both periods.

CONCLUSIONS

The implementation of a paper-based MMF alone was insufficient to bridge the guideline-practice gap in metabolic monitoring, highlighting the need for other or concurrent strategies to achieve improvement.

摘要

背景

抗精神病药物的代谢不良反应给精神障碍患者带来了重大健康风险。尽管临床实践指南建议进行定期代谢监测,但在精神科环境中,对这些建议的遵循情况仍不尽人意。

目的

本质量改进项目旨在评估在加拿大一个大城市的门诊精神科诊所,一份基于纸质的组织代谢监测表(MMF)对接受抗精神病药物治疗的精神障碍患者监测实践的影响。

方法

开展了一项干预前后研究,以评估MMF对75名随机选择的符合条件患者年度监测的影响。在引入该表格之前和之后的1年,对代谢监测参数(血压、体重、腰围以及血糖和血脂谱)进行了审查。

结果

10份病历中没有MMF,尽管其余病历中有该表格,但代谢参数记录没有改善,总体指南遵循率仍然很低。空腹血糖和糖化血红蛋白测量最常被安排,而两个时期的血压和体重测量一直较少。

结论

仅实施基于纸质的MMF不足以弥合代谢监测中指南与实践之间的差距,这突出表明需要其他或同时采取策略来实现改进。

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