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黏土-水界面动力学诱导原始RNA的聚合与复制

Polymerization and replication of primordial RNA induced by clay-water interface dynamics.

作者信息

Alejandre Carla, Aguirre-Tamaral Adrián, Briones Carlos, Aguirre Jacobo

机构信息

Centro de Astrobiología (CAB), CSIC-INTA, Torrejón de Ardoz, Madrid, Spain.

Grupo Interdisciplinar de Sistemas Complejos (GISC), Madrid, Spain.

出版信息

Commun Chem. 2025 Aug 7;8(1):236. doi: 10.1038/s42004-025-01632-w.

Abstract

In the study of life's origins, a key challenge is understanding how RNA could have polymerized and subsequently replicated in early Earth. We present a theoretical and computational framework to model the non-enzymatic polymerization of ribonucleotides and the template-dependent replication of primordial RNA molecules, at the interfaces between the aqueous solution and a clay mineral. Our results demonstrate that systematic polymerization and replication of single-stranded RNA polymers, sufficiently long to fold and acquire basic functions (>15 nt), were feasible under these conditions. Crucially, this process required a physico-chemical environment characterized by large-amplitude oscillations with periodicity compatible with spring tide dynamics, suggesting that large moons may have played a role in the emergence of RNA-based life on planetary bodies. Interestingly, the theoretical analysis presents rigorous evidence that RNA replication efficiency increases in oscillating environments compared to constant ones. Moreover, the versatility of our framework enables comparisons between different genetic alphabets, showing that a four-letter alphabet -particularly when allowing non-canonical base pairs, as in current RNA- represents an optimal balance of replication speed and sequence diversity in the pathway to life.

摘要

在生命起源的研究中,一个关键挑战是理解RNA在早期地球上是如何聚合并随后进行复制的。我们提出了一个理论和计算框架,用于模拟核糖核苷酸在水溶液与粘土矿物界面处的非酶促聚合以及原始RNA分子的模板依赖性复制。我们的结果表明,在这些条件下,单链RNA聚合物进行系统聚合和复制是可行的,这些聚合物足够长以折叠并获得基本功能(>15个核苷酸)。至关重要的是,这个过程需要一个具有大振幅振荡且周期与大潮动力学相匹配的物理化学环境,这表明大型卫星可能在行星体上基于RNA的生命出现过程中发挥了作用。有趣的是,理论分析提供了确凿证据,表明与恒定环境相比,振荡环境中RNA复制效率会提高。此外,我们框架的通用性使得能够对不同遗传字母表进行比较,结果表明四个字母的字母表——特别是像当前RNA那样允许非标准碱基对时——在通向生命的途径中代表了复制速度和序列多样性的最佳平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab4/12332015/8dac7018a60b/42004_2025_1632_Fig1_HTML.jpg

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