背景决定一切：类Polo激酶I在秀丽隐杆线虫卵母细胞减数分裂过程中的作用
Context is everything: The role of polo-like kinase I during C. elegans oocyte meiosis.
作者信息
Bhalla Needhi
机构信息
Department of Molecular, Cell and Developmental Biology, Sinsheimer Labs, University of California, Santa Cruz, Santa Cruz, CA, USA.
出版信息
J Cell Biol. 2025 Sep 1;224(9). doi: 10.1083/jcb.202506208. Epub 2025 Aug 8.
Abstract
Meiotic chromosome segregation in oocytes often relies on meiosis-specific modifications of mitotic molecular mechanisms to respond to the unique challenges of this asymmetric division. In this issue, Narula and Wignall (https://doi.org/10.1083/jcb.202503080) demonstrate how the conserved polo-like kinase in Caenorhabditiselegans, PLK-1, has been repurposed in unexpected ways to ensure accurate meiotic chromosome segregation during oogenesis.
摘要
卵母细胞中的减数分裂染色体分离通常依赖于有丝分裂分子机制的减数分裂特异性修饰，以应对这种不对称分裂的独特挑战。在本期中，纳鲁拉和威格纳尔（https://doi.org/10.1083/jcb.202503080）展示了秀丽隐杆线虫中保守的polo样激酶PLK-1是如何以意想不到的方式被重新利用，以确保卵子发生过程中减数分裂染色体的准确分离。
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本文引用的文献
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