Hill R, Schmidt S, Evancho M, Hunter T, Hillegass D, Sharp W
J Biomed Mater Res. 1985 Sep;19(7):827-32. doi: 10.1002/jbm.820190708.
The pathology of thrombophlebitis primarily results from the obliteration of venous valves in the lower extremities. The objective of this study was to develop a prosthetic venous valve that could be implanted in the human femoral system to ameliorate the deleterious effects of thrombophlebitis. Prosthetic venous valves were produced from two materials: Pellethane valves were fabricated from a dip-casting process; umbilical vein valves were produced by a fixation process. The valves were evaluated as implants within the external jugular veins of 10 research dogs. Each animal was implanted with one Pellethane valve in one external jugular vein and one umbilical vein venous valve in the contralateral jugular vein. Each valve was positioned over a stainless-steel cylinder that had been implanted into the jugular veins in such a manner that there existed no blood-cylinder interaction. Patency of the valves was determined by X-ray venography at 24, 48, and 72 h and at 5 and 8 days postoperatively. All of the umbilical vein venous valves were occluded by the end of 48 h, whereas two of the Pellethane venous valves remained patent for at least 5 days but were occluded at 8 days. The results of this study suggest the possibility of success of Pellethane valve implants in the venous circulation and indicate future directions for study.
血栓性静脉炎的病理主要源于下肢静脉瓣膜的闭塞。本研究的目的是开发一种可植入人体股静脉系统的人工静脉瓣膜，以改善血栓性静脉炎的有害影响。人工静脉瓣膜由两种材料制成：聚醚酯瓣膜通过浸铸工艺制造；脐静脉瓣膜通过固定工艺制造。这些瓣膜作为植入物在10只实验犬的颈外静脉中进行评估。每只动物在一侧颈外静脉植入一个聚醚酯瓣膜，在对侧颈静脉植入一个脐静脉瓣膜。每个瓣膜放置在一个已植入颈静脉的不锈钢圆柱体上，放置方式使得不存在血液与圆柱体的相互作用。通过术后24、48和72小时以及5天和8天的X线静脉造影来确定瓣膜的通畅情况。所有脐静脉瓣膜在48小时结束时均闭塞，而两个聚醚酯静脉瓣膜至少在5天内保持通畅，但在8天时闭塞。本研究结果表明聚醚酯瓣膜植入静脉循环成功的可能性，并指出了未来的研究方向。
