Parents of children diagnosed with autism spectrum disorder (ASD) often face elevated psychological distress, including symptoms of post-traumatic stress disorder (PTSD). This study explored whether perceived social support moderates the relationship between parental gender and PTSD risk. A cross-sectional correlational study was conducted among 142 Arabic-speaking parents (equally distributed between mothers and fathers) recruited from 10 ASD treatment centers in central Jordan. Participants completed standardized measures of PTSD symptoms and perceived social support, along with demographic and child-related information. Two hierarchical linear regression models were employed to examine whether perceived social support moderated the association between parental gender and PTSD symptoms, controlling for relevant covariates. The mean PTSD score among parents was 42.08, surpassing the clinical risk threshold of 33. Mothers reported significantly higher PTSD scores compared to fathers. Elevated PTSD symptoms were also observed among parents with low levels of perceived social support and those caring for children with more severe ASD symptoms. Hierarchical regression analysis revealed that perceived social support significantly moderated the relationship between parental gender and PTSD symptoms. Specifically, mothers with low perceived social support exhibited the highest levels of PTSD symptoms, whereas fathers with high support showed the lowest. The final regression model explained 61% of the variance in PTSD scores. Perceived social support serves as a significant moderating factor in the relationship between parental gender and PTSD risk among parents of children with ASD. Targeted interventions that strengthen social support-particularly for mothers-may help reduce PTSD symptoms and enhance the psychological well-being of caregivers in ASD-affected families.