Mazzoni Agustina, Berrueta Mabel, Pingray Veronica, Babinska Magdalena, Nigri Carolina, Ortega Vanesa, Salva Florencia, Ciapponi Agustín, Bonet Mercedes
Institute for Clinical Effectiveness and Health Policy, Emilio Ravignani 2024 (C1414CPV), Buenos Aires, Argentina.
UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Organization, Av. Appia 20, Geneva, 1211, Switzerland.
Matern Health Neonatol Perinatol. 2025 Aug 11;11(1):23. doi: 10.1186/s40748-025-00215-w.
OBJECTIVE: To systematically identify and classify maternal and perinatal health outcomes reported in research conducted in the epidemic and pandemic context. STUDY DESIGN AND SETTING: We conducted a systematic review following Cochrane Methods. We searched MEDLINE, EMBASE, LILACS, SCI-EXPANDED, CINAHL, Cochrane Central Register of Controlled Trials, PsycINFO, AMED, ClinicalTrials.gov and ICTRP, between January 2015 and March 2023. Experimental, quasi-experimental, observational studies, phase IV trials, and post-marketing studies, published protocols and ongoing registered studies reporting maternal and perinatal health outcomes were included. Studies only reporting coverage of interventions, access to routine health services, clinical presentation of infectious diseases, and reviews were excluded. A sampling strategy was used for COVID-19 studies, due to their very high numbers. Outcome verbatims were extracted and categorized in unique outcome, and further classified into domains and subdomains. Frequency of outcome reporting was calculated. RESULTS: 94 maternal and pregnancy and 47 unique neonatal outcomes were identified, from a total of 917 and 657 verbatims, respectively, reported across 440 included studies. At least 20% of included studies reported maternal and pregnancy outcomes of mode of delivery (56.1%), stillbirth (33.0%), preterm birth (28.6%), hypertensive disorders of pregnancy (26.6%), and maternal death (20.7%). These outcomes were identified across all three types of studies identified (epidemiological, product development or post-authorization surveillance). Gestational age at birth (29.8%), congenital malformations of the nervous system (26.1%), birth weight (23.4%), neonatal admission to intensive care unit (23.2%), and neonatal death (19.1%) were the most frequently reported neonatal outcomes. CONCLUSIONS: Our study provides the basis for developing a core outcome set to measure maternal and perinatal health during outbreaks, which would help improve data collection of harmonized data, data synthesis, and timely development of informed public health guidance and clinical care responding to the needs of pregnant women.
目的：系统识别并分类在疫情和大流行背景下开展的研究中报告的孕产妇和围产期健康结局。 研究设计与背景：我们按照Cochrane方法进行了一项系统综述。我们检索了2015年1月至2023年3月期间的MEDLINE、EMBASE、LILACS、SCI-EXPANDED、CINAHL、Cochrane对照试验中央注册库、PsycINFO、AMED、ClinicalTrials.gov和ICTRP。纳入了报告孕产妇和围产期健康结局的实验性、准实验性、观察性研究、IV期试验以及上市后研究、已发表的方案和正在进行的注册研究。仅报告干预措施覆盖范围、获得常规卫生服务情况、传染病临床表现以及综述的研究被排除。由于COVID-19研究数量众多，因此对其采用了抽样策略。提取结局逐字记录并归类为独特结局，然后进一步分为领域和子领域。计算结局报告的频率。 结果：在纳入的440项研究中，分别从总共917条和657条逐字记录中识别出94项孕产妇和妊娠结局以及47项独特的新生儿结局。至少20%的纳入研究报告了分娩方式（56.1%）、死产（33.0%）、早产（28.6%）、妊娠高血压疾病（26.6%）和孕产妇死亡（20.7%）等孕产妇和妊娠结局。这些结局在所有三种类型的研究（流行病学、产品开发或上市后监测）中均有发现。出生孕周（29.8%）、神经系统先天性畸形（26.1%）、出生体重（23.4%）、新生儿入住重症监护病房（23.2%）和新生儿死亡（19.1%）是报告最频繁的新生儿结局。 结论：我们的研究为制定一套核心结局集以衡量疫情期间的孕产妇和围产期健康提供了依据，这将有助于改善统一数据的数据收集、数据综合，并及时制定符合孕妇需求的明智公共卫生指南和临床护理。
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