Zhang Keyu, Wang Guanyun, Wang Xiaoya, Zhou Ziang, Kan Ying, Wang Wei, Yang Jigang
Nuclear Medicine Department, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Quant Imaging Med Surg. 2025 Aug 1;15(8):6682-6691. doi: 10.21037/qims-2025-524. Epub 2025 Jul 17.
Congenital neuroblastoma represents an early-onset form of neuroblastoma. This study aims to evaluate the imaging features of I-metaiodobenzylguanidine (I-MIBG) single-photon emission computed tomography (SPECT)/computed tomography (CT) and their correlation with the clinical characteristics of localized congenital neuroblastoma.
We retrospectively collected imaging and clinical data from congenital neuroblastoma patients who underwent I-MIBG SPECT/CT. The volumes of interest of primary lesion, muscle, lung and mediastinum blood pool were delineated by 3DSlicer. The ratios of the maximum and average counts between the tumor and muscle/lung/mediastinum blood pool were calculated to explore the factors related to the spontaneous regression of the tumor.
A total of 11 patients with localized congenital neuroblastoma were included in this study. The majority of the lesions were identified prenatally. I-MIBG imaging demonstrated that all of the spontaneous regressed lesions were localized neuroblastoma, which did not cross the midline and were negative for image-defined risk factors, with a maximum diameter of less than 3.1 cm. The I-MIBG uptake in the tumor was significantly associated with spontaneous regression of neuroblastoma. Lower I-MIBG uptake in the tumor is associated with spontaneous tumor regression of neuroblastoma.
I-MIBG SPECT/CT is a valuable tool for the diagnosis, staging and monitoring of treatment response in congenital neuroblastoma. The I-MIBG uptake of the tumor can predict the spontaneous regression in localized congenital neuroblastoma.
先天性神经母细胞瘤是神经母细胞瘤的一种早发型形式。本研究旨在评估碘-间位碘代苄胍（I-MIBG）单光子发射计算机断层扫描（SPECT）/计算机断层扫描（CT）的成像特征及其与局限性先天性神经母细胞瘤临床特征的相关性。
我们回顾性收集了接受I-MIBG SPECT/CT检查的先天性神经母细胞瘤患者的影像和临床数据。通过3DSlicer勾勒出原发灶、肌肉、肺和纵隔血池的感兴趣区。计算肿瘤与肌肉/肺/纵隔血池之间的最大计数比和平均计数比，以探索与肿瘤自发消退相关的因素。
本研究共纳入11例局限性先天性神经母细胞瘤患者。大多数病变在产前被发现。I-MIBG成像显示，所有自发消退的病变均为局限性神经母细胞瘤，未跨越中线且图像定义的危险因素为阴性，最大直径小于3.1 cm。肿瘤中的I-MIBG摄取与神经母细胞瘤的自发消退显著相关。肿瘤中较低的I-MIBG摄取与神经母细胞瘤的自发肿瘤消退相关。
I-MIBG SPECT/CT是先天性神经母细胞瘤诊断、分期及治疗反应监测的有价值工具。肿瘤的I-MIBG摄取可预测局限性先天性神经母细胞瘤的自发消退。
