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无存活能力的死产:单绒毛膜双胎妊娠中双胎反向动脉灌注序列(TRAP)的产时诊断。

Stillbirth Without Viability: An Intrapartum Diagnosis of Twin Reversed Arterial Perfusion (TRAP) Sequence in Monochorionic Twin Pregnancy.

作者信息

Siwatch Sujata, Sodhi Rohan, Khastgir Gaurav, Sikka Pooja

机构信息

Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.

出版信息

Cureus. 2025 Jul 8;17(7):e87555. doi: 10.7759/cureus.87555. eCollection 2025 Jul.

DOI:10.7759/cureus.87555
PMID:40786434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12331543/
Abstract

Twin reversed arterial perfusion (TRAP) sequence is a rare complication of monochorionic twin pregnancies, characterised by a nonviable acardiac twin perfused by a structurally normal "pump" twin. We report a case of a 33-year-old woman, G4P2012, who presented at 29 weeks in advanced labour with a history of inadequate antenatal care. She delivered a live male neonate, followed by the unexpected delivery of an intrauterine mass initially suspected to be a fibroid. Further evaluation revealed the mass to be an acardiac twin, and placental examination confirmed monochorionic diamniotic placentation, establishing the diagnosis of TRAP sequence. This case highlights the critical importance of early and detailed antenatal ultrasonography in twin pregnancies. It also raises important questions regarding the classification of stillbirths in the context of severe congenital anomalies incompatible with life.

摘要

双胎反向动脉灌注序列征(TRAP)是单绒毛膜双胎妊娠的一种罕见并发症,其特征为一个无生机的无心双胎由结构正常的“泵血”双胎供血。我们报告一例33岁女性,孕4产2012,在孕29周时因产前检查不足前来就诊,处于晚期分娩状态。她产下一名存活男婴,随后意外娩出一个最初怀疑为肌瘤的子宫内肿物。进一步评估显示该肿物为无心双胎,胎盘检查证实为单绒毛膜双羊膜囊胎盘,从而确诊为TRAP序列征。该病例凸显了双胎妊娠早期详细产前超声检查的至关重要性。它还引发了关于严重先天性异常导致的死胎在与生命不相容情况下分类的重要问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0343/12331543/88ec42ab3f99/cureus-0017-00000087555-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0343/12331543/88ec42ab3f99/cureus-0017-00000087555-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0343/12331543/88ec42ab3f99/cureus-0017-00000087555-i01.jpg

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本文引用的文献

1
Twin Reversed Arterial Perfusion Sequence: Prenatal Diagnosis and Treatment.双胎反向动脉灌注序列征:产前诊断与治疗
Matern Fetal Med. 2022 Sep 24;4(4):262-267. doi: 10.1097/FM9.0000000000000172. eCollection 2022 Oct.
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Twin reverse arterial perfusion: Timing of intervention.双反向动脉灌注:干预时机。
Best Pract Res Clin Obstet Gynaecol. 2022 Nov;84:127-142. doi: 10.1016/j.bpobgyn.2022.03.006. Epub 2022 Mar 29.
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Acardiac twin pregnancies part VI: Why does acardiac twinning occur only in the first trimester?无心双胎妊娠 第六部分:为何无心双胎仅发生于孕早期?
Birth Defects Res. 2021 May 15;113(9):687-695. doi: 10.1002/bdr2.1882. Epub 2021 Feb 12.
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A review of stillbirth definitions: A rationale for change.死产定义综述:变革的理由。
Eur J Obstet Gynecol Reprod Biol. 2021 Jan;256:235-245. doi: 10.1016/j.ejogrb.2020.11.015. Epub 2020 Nov 18.
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Twin Reversed Arterial Perfusion Sequence: Current Treatment Options.双胎反向动脉灌注序列征:当前的治疗选择
Int J Womens Health. 2020 May 28;12:435-443. doi: 10.2147/IJWH.S214254. eCollection 2020.
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Conservative management in a case of uncomplicated trap sequence: a case report and brief literature review.单纯性脊柱裂序列征病例的保守治疗:一例报告及文献简要综述
J Prenat Med. 2015 Jul-Dec;9(3-4):29-34. doi: 10.11138/jpm/2015.9.3.029.
7
Microwave Ablation for Twin-Reversed Arterial Perfusion Sequence: A Novel Application of Technology.微波消融治疗双胎反向动脉灌注序列征:一项技术的新应用
Fetal Diagn Ther. 2015;38(1):35-40. doi: 10.1159/000369384. Epub 2015 Jan 22.
8
Optimal method and timing of intrauterine intervention in twin reversed arterial perfusion sequence: case study and meta-analysis.双胎反向动脉灌注序列中宫内干预的最佳方法和时机:病例研究与荟萃分析
Fetal Diagn Ther. 2014;35(4):267-79. doi: 10.1159/000358593. Epub 2014 Apr 16.
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The monozygotic twinning process, the twin-twin transfusion syndrome and acardiac twins.单卵孪生过程、双胎输血综合征和无心畸形双胎。
Placenta. 2009 Nov;30(11):923-8. doi: 10.1016/j.placenta.2009.08.009. Epub 2009 Sep 12.
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