重症监护病房中嗜酸性粒细胞减少及中性粒细胞与淋巴细胞比值与脓毒症相关死亡率的关系。
Relationship between eosinopenia and neutrophil-lymphocyte ratio with sepsis-related mortality in the intensive care unit.
作者信息
Amri Parviz, Nejadnaderi Armin, Gholinia Hemmat, Heidarnia Fatemeh, Bayani Masomeh
机构信息
Clinical Research Development Unit of Ayatollah Rouhani Hospital, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
出版信息
Caspian J Intern Med. 2025 Jun 23;16(3):444-450. doi: 10.22088/cjim.16.3.444. eCollection 2025 Summer.
BACKGROUND
Early diagnosis of sepsis can lead to rapid initiation of treatment and reduced mortality. The aim of this study was to investigate the relationship between eosinopenia and neutrophil-lymphocyte ratio (NLR) with sepsis-related mortality in the intensive care unit.
RESULTS
Out of 100 patients studied, 59 patients survived and 41 patients died and the mean age of the patients was 63.27±16.13 years. Out of 40 patients with eosinopenia, 19(46.3%) died and out of 60 patients with normal eosinophil, 22(53.7%) died (P=0.28). The NLR on the first day in died patients was significantly higher than in the surviving patients (P=0.009). The increase in SOFA Score (p<0.001 and OR=1.49) and the increase in NLR (P=0.02 and OR=3.38) has a direct relationship with the mortality rate.
CONCLUSION
The results of the present study in sepsis patients showed that patients who had a higher neutrophil-to-lymphocyte ratio had higher mortality and there was no relationship between eosinopenia and mortality rate.
背景
脓毒症的早期诊断可促使治疗迅速启动并降低死亡率。本研究旨在探讨重症监护病房中嗜酸性粒细胞减少症和中性粒细胞与淋巴细胞比值（NLR）与脓毒症相关死亡率之间的关系。
结果
在研究的100例患者中，59例存活，41例死亡，患者的平均年龄为63.27±16.13岁。在40例嗜酸性粒细胞减少症患者中，19例（46.3%）死亡；在60例嗜酸性粒细胞正常的患者中，22例（53.7%）死亡（P=0.28）。死亡患者第一天的NLR显著高于存活患者（P=0.009）。序贯器官衰竭评估（SOFA）评分的增加（p<0.001，比值比[OR]=1.49）和NLR的增加（P=0.02，OR=3.38）与死亡率直接相关。
结论
本研究中脓毒症患者的结果表明，中性粒细胞与淋巴细胞比值较高的患者死亡率较高，且嗜酸性粒细胞减少症与死亡率之间无相关性。
Zotero 插件