Chisolm J J, Thomas D J
J Pharmacol Exp Ther. 1985 Dec;235(3):665-9.
2,3-Dimercaptopropane-1-sulfonate (DMPS) is a water-soluble metal complexing agent. Administration to lead-poisoned children of 5-day courses of 200 or 400 mg of DMPS per m2 surface area per day given p.o. in divided doses resulted in a significant decline in the concentration of lead in blood. DMPS treatment did not significantly alter the concentrations of zinc or copper in plasma. Urinary excretion of lead, zinc and copper was increased by DMPS administration and these increases were sustained throughout the 5-day course of treatment. No significant changes in hepatic, renal or hematological function were found in DMPS-treated children and no side effects attributable to DMPS were noted. It is concluded that a 5-day course of DMPS given p.o. may be safe and effective in the treatment of asymptomatic lead poisoning in children.
2,3-二巯基丙烷-1-磺酸盐（DMPS）是一种水溶性金属络合剂。对铅中毒儿童口服给予DMPS，每天每平方米表面积200或400毫克，分剂量服用，疗程为5天，结果血铅浓度显著下降。DMPS治疗并未显著改变血浆中锌或铜的浓度。给予DMPS后，铅、锌和铜的尿排泄量增加，且在整个5天疗程中持续增加。接受DMPS治疗的儿童未发现肝、肾或血液学功能有显著变化，也未观察到归因于DMPS的副作用。结论是，口服5天疗程的DMPS可能对治疗儿童无症状铅中毒安全有效。
