Jin Xing, Wang Yuxing, Jiang Hui, Wu Ying, Liu Yi
Department of Anesthesiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
School of Humanities and Social Sciences, Research Center for Psychological and Health Sciences, Shanxi Medical University, Taiyuan, China.
Front Psychiatry. 2025 Jul 25;16:1611129. doi: 10.3389/fpsyt.2025.1611129. eCollection 2025.
Women with breast cancer are prone to moderate to severe preoperative anxiety. Effective measures for preventing and managing preoperative anxiety include drug therapy and non-drug intervention. The main evaluation method is scale assessment, which has certain limitations and may involve human concealment or evaluation errors. In this study, resting-state electroencephalography (EEG) was used to explore changes in power spectrum during the alleviation of preoperative anxiety in breast cancer patients, which is of great significance for objectively identifying and evaluating preoperative anxiety in patients.
40 breast cancer patients were randomly divided into two groups (20 patients per group), receiving either psychological intervention (PI) or intravenous midazolam (MID) before surgery. Visual Analog Scale for Anxiety (VAS-A) and Observer's assessment alert/Sedation (OAA/S) scores, clinical monitoring indexes and EEG data were measured before and after intervention.
VAS-A scores significantly decreased in both groups (p < 0.05), the power in the theta band of the frontal parietal regions decreased (p < 0.05) and was positively correlated with VAS-A scores (p < 0.001). Network analysis revealed that the three highest centrality measures in the PI group were located in the alpha band frontal parietal region, frontal central region, and gamma band parietal region, while the OAA/S scores showed the highest centrality for all three measures in the MID group.
Both PI and intravenous MID can effectively alleviate preoperative anxiety in breast cancer patients, but their neuroelectrophysiological mechanisms were not entirely the same. Regarding the relationship between brain region power and monitoring indexes, the power of three specific regions in certain frequency bands was the primary factor in the PI group, while the level of sedation was the determining factor in the MID group.
乳腺癌女性患者术前容易出现中度至重度焦虑。预防和管理术前焦虑的有效措施包括药物治疗和非药物干预。主要评估方法是量表评估，其存在一定局限性，可能涉及人为隐瞒或评估误差。本研究采用静息态脑电图（EEG）来探究乳腺癌患者术前焦虑缓解过程中功率谱的变化，这对于客观识别和评估患者术前焦虑具有重要意义。
40例乳腺癌患者随机分为两组（每组20例），术前分别接受心理干预（PI）或静脉注射咪达唑仑（MID）。在干预前后测量焦虑视觉模拟量表（VAS-A）和观察者警觉/镇静评估（OAA/S）评分、临床监测指标及EEG数据。
两组VAS-A评分均显著降低（p < 0.05），额顶叶区域θ频段功率降低（p < 0.05），且与VAS-A评分呈正相关（p < 0.001）。网络分析显示，PI组中中心性最高的三个指标位于α频段额顶叶区域、额中央区域和γ频段顶叶区域，而在MID组中，OAA/S评分在所有三个指标中中心性最高。
PI和静脉注射MID均可有效缓解乳腺癌患者术前焦虑，但它们的神经电生理机制并不完全相同。关于脑区功率与监测指标之间的关系，PI组中特定频段三个特定区域的功率是主要因素，而MID组中镇静水平是决定因素。
