Estrogen use and cardiovascular disease.

In general, epidemiologic data from case-control and cohort studies have suggested that postmenopausal estrogen use confers a moderate degree of protection from coronary artery disease (CAD). Reductions have been found in all-cause mortality and mortality from acute myocardial infarction among estrogen replacement users as compared with never-users. Even a small decline in the death rate from CAD among estrogen users would have a major impact on the overall risk:benefit ratio associated with estrogen use.