Li Junjun, Wu Chuanjiang, Liu Qinjun, Liu Mingqi, Liu Ting, Li Airui, Fu Guangchao, Zou Zhiyong, Guo Daqing, Chen Ke, Xia Yang, Yao Dezhong
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, China.
iScience. 2025 Jul 21;28(8):113168. doi: 10.1016/j.isci.2025.113168. eCollection 2025 Aug 15.
Rhythm perception is considered a conserved trait across species, and musical rhythm exposure (MRE) has been demonstrated to enhance cognitive functions in healthy individuals. Alzheimer's disease (AD), characterized by cognitive decline and pathological degeneration, may potentially be delayed by MRE. In this study, the APP/PS1 AD mouse model was exposed to Mozart's K.448 rhythm for six months, with APP/PS1 and wild-type C57BL/6J mice serving as controls. The Morris water maze test was employed to assess the impact of MRE on spatial learning and memory. Pathological damage was evaluated through amyloid-beta and phosphorylated tau levels. Additionally, hippocampal microglia activation, inflammatory markers, and gut microbiota composition were analyzed. The study revealed that MRE improves cognitive function, reduces amyloid plaque accumulation, suppresses microglial activation and neuroinflammation, and modulates gut microbiota composition. This suggests that MRE offers a promising non-pharmacological approach to slowing cognitive decline and pathological damage in AD.
节奏感知被认为是跨物种的保守特征，并且音乐节奏暴露（MRE）已被证明可增强健康个体的认知功能。以认知衰退和病理退化为特征的阿尔茨海默病（AD）可能会被MRE潜在地延缓。在本研究中，将APP/PS1 AD小鼠模型暴露于莫扎特的K.448节奏中六个月，以APP/PS1和野生型C57BL/6J小鼠作为对照。采用莫里斯水迷宫试验评估MRE对空间学习和记忆的影响。通过β-淀粉样蛋白和磷酸化tau蛋白水平评估病理损伤。此外，还分析了海马小胶质细胞活化、炎症标志物和肠道微生物群组成。研究表明，MRE可改善认知功能，减少淀粉样斑块积累，抑制小胶质细胞活化和神经炎症，并调节肠道微生物群组成。这表明MRE为减缓AD的认知衰退和病理损伤提供了一种有前景的非药物方法。
