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医源性乳内动脉与心大静脉吻合术:巴勒斯坦首例文献记载病例报告及文献综述

Iatrogenic anastomosis of the internal mammary artery with the great cardiac vein: The first documented case report in Palestine with a literature review.

作者信息

Warasna Haya Jebreen Mohammed, Sabboh Maya, Awad Mohammad Yaser Hasan, Awad Bashar Yaser Hasan, Warasna Ahmad J, Alhadad Baha, Zreqat Qusai N

机构信息

Faculty of Medicine, Palestine Polytechnic University, Hebron, Palestine.

Faculty of Medicine, Tishreen University, Latakia, Syria.

出版信息

Medicine (Baltimore). 2025 Aug 8;104(32):e43670. doi: 10.1097/MD.0000000000043670.

Abstract

RATIONALE

An unintentional anastomosis of the left internal mammary artery (LIMA) to the great cardiac vein (GCV) is a rare complication of coronary artery bypass graft surgery (CABG), resulting in a left-to-right arteriovenous shunt. It may cause angina, arrhythmias, or right-sided heart failure, with symptoms sometimes delayed for years. Management varies based on symptoms and hemodynamic impact, ranging from conservative to surgical intervention.

PATIENT CONCERNS

A 60-year-old male presented with recurrent exertional chest pain described as heavy, nonradiating, and relieved by rest. The pain was associated with nausea and sweating. He had a past medical history of ischemic heart disease, chronic obstructive pulmonary disease, hypertension, type 2 diabetes, hyperlipidemia, and a history of supraventricular tachycardia treated with ablation. He was a smoker and had previously undergone CABG in 2020.

DIAGNOSES

Electrocardiography revealed ST-segment depression in leads V4-V6 and T-wave inversion in inferior leads. Troponin was negative. Coronary angiography revealed an iatrogenic LIMA-GCV anastomosis instead of the intended left anterior descending (LAD), along with severe (95%) proximal LAD stenosis and additional mid-LAD disease. Echocardiography showed preserved left ventricular function (ejection fraction 60%).

INTERVENTIONS

The patient underwent percutaneous transluminal coronary angioplasty with drug-eluting stents (Onyx 3.5/18 mm and Xience 2.5/18 mm) to the proximal and mid-LAD segments. No intervention was performed on the nondominant right coronary artery or the LIMA-GCV fistula during this admission.

OUTCOMES

The patient experienced complete resolution of symptoms postintervention. The recovery was uneventful, and he was discharged on the second day of hospitalization.

LESSONS

Iatrogenic aortocoronary arteriovenous fistula is a rare but important complication of CABG, which can lead to significant clinical symptoms. Early diagnosis through coronary angiography is crucial for guiding appropriate management. Although percutaneous intervention with drug-eluting stents effectively resolved the patient's angina by treating the native LAD stenosis, it is critical to recognize that this approach did not address the underlying LIMA-GCV fistula, which requires separate evaluation and management.

摘要

原理

左乳内动脉(LIMA)与大心脏静脉(GCV)意外吻合是冠状动脉旁路移植术(CABG)的一种罕见并发症,会导致从左向右的动静脉分流。它可能引起心绞痛、心律失常或右侧心力衰竭,症状有时会延迟数年出现。治疗方法根据症状和血流动力学影响而有所不同,范围从保守治疗到手术干预。

患者情况

一名60岁男性因反复出现劳力性胸痛前来就诊,胸痛性质为沉重感、无放射痛,休息后缓解。疼痛伴有恶心和出汗。他有缺血性心脏病、慢性阻塞性肺疾病、高血压、2型糖尿病、高脂血症病史,曾接受过房室结折返性心动过速消融治疗。他是一名吸烟者,2020年曾接受过冠状动脉旁路移植术。

诊断

心电图显示V4-V6导联ST段压低,下壁导联T波倒置。肌钙蛋白阴性。冠状动脉造影显示医源性LIMA-GCV吻合,而非预期的左前降支(LAD),同时LAD近端严重狭窄(95%),且LAD中段还有病变。超声心动图显示左心室功能正常(射血分数60%)。

干预措施

患者接受了药物洗脱支架(Onyx 3.5/18 mm和Xience 2.5/18 mm)的经皮腔内冠状动脉成形术,分别植入LAD近端和中段。此次住院期间,对非优势右冠状动脉或LIMA-GCV瘘未进行干预。

结果

干预后患者症状完全缓解。恢复过程顺利,住院第二天出院。

经验教训

医源性主动脉冠状动脉瘘是冠状动脉旁路移植术的一种罕见但重要的并发症,可导致明显的临床症状。通过冠状动脉造影进行早期诊断对于指导适当的治疗至关重要。虽然药物洗脱支架的经皮干预通过治疗LAD自身狭窄有效缓解了患者的心绞痛,但必须认识到这种方法并未解决潜在的LIMA-GCV瘘,后者需要单独评估和处理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75d4/12338290/589c68786257/medi-104-e43670-g006.jpg

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