Merola Angela, Baldino Lucia, Procentese Alessandra
Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
Nanomaterials (Basel). 2025 Jul 24;15(15):1149. doi: 10.3390/nano15151149.
Nanocarriers have found numerous applications in pharmaceutical and food sectors due to their unique physical and chemical properties. In particular, liposomes are the most extensively studied kind of nanoparticles for these applications. They are spherical colloidal systems characterized by lipid membranes enclosing an aqueous core. This versatile structure enables the incorporation of hydrophilic, hydrophobic, and amphiphilic molecules, making them optimal candidates for the controlled release of drugs and enzymes. Despite numerous promising applications, liposomes face challenges such as low colloidal stability, inefficient drug encapsulation, and high production costs for large-scale applications. For this reason, innovative methods, such as microfluidics, electroporation, and supercritical CO, are currently being investigated to overcome these limitations. This review examines the recent applications of liposomes in enzyme encapsulation within the pharmaceutical and food sectors, emphasizing production challenges and emerging technological developments.
由于其独特的物理和化学性质，纳米载体在制药和食品领域有众多应用。特别是，脂质体是这些应用中研究最为广泛的一类纳米颗粒。它们是球形胶体系统，其特征是由脂质膜包裹着一个水相核心。这种多功能结构能够包载亲水性、疏水性和两亲性分子，使其成为药物和酶控释的理想候选者。尽管有许多有前景的应用，但脂质体面临着诸如胶体稳定性低、药物包封效率低以及大规模应用生产成本高等挑战。因此，目前正在研究微流体、电穿孔和超临界二氧化碳等创新方法来克服这些限制。本综述考察了脂质体在制药和食品领域酶包封方面的最新应用，强调了生产挑战和新兴技术发展。
