Abdul Jabbar Ali Bin, Mansoor Taha, Osborne John, Gilkeson Kyle, Chinawalkar Ameya, Aboeata Ahmed
Department of Medicine, Division of Internal Medicine, Creighton University School of Medicine, 7710 Mercy Road, Suite 301, Omaha, NE, 68124-2368, USA.
Department of Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA.
BMC Cardiovasc Disord. 2025 Aug 13;25(1):601. doi: 10.1186/s12872-025-05029-4.
Obesity is a growing cause of heart failure (HF) mortality in the younger population. However, trends and disparities in HF and obesity-related mortality in the middle-aged and young adult population of the US are not well studied. In this study, we aim to evaluate obesity and HF-related mortality trends for middle-aged and young adults and compare them among demographic and regional population subgroups.
Data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) were used to analyze death certificates from 1999 to 2022 for HF and obesity-related mortality in the middle-aged and young adult population of United States residents (aged 25-64). Age-adjusted mortality rates (AAMRs) per 100,000 people and annual percent changes (APCs) were calculated using Joinpoint regression analysis.
From 1999 to 2022, there were a total of 58,290 deaths attributable to obesity and HF in middle-aged and young Americans. Overall, the age-adjusted mortality rate increased by 337% from 0.72 in 1999 to a peak of 3.15 in 2021. The AAMR increased by 154% from 0.72 in 1999 to 183 in 2019, with an average APC of 4.90 (95% CI 4.57-5.33). The proportion of HF-related deaths associated with obesity increased almost threefold, from 4.5% in 1999 to a peak of 12.45% in 2021. Men and non-Hispanic (NH) Black people had higher mortality rates throughout the study period, with worsening disparities. Worsening disparities were also observed in the southern US and rural areas.
Obesity-associated HF mortality in the young adult population of the US has increased since 1999, with worsening disparities. Men, NH Black people, the southern region, and rural areas have been disproportionately affected.
肥胖是导致年轻人群心力衰竭（HF）死亡的一个日益重要的原因。然而，美国中年和青年人群中与心力衰竭及肥胖相关的死亡率趋势和差异尚未得到充分研究。在本研究中，我们旨在评估中年和青年成年人中肥胖与心力衰竭相关的死亡率趋势，并在人口统计学和区域人群亚组之间进行比较。
使用美国疾病控制与预防中心的广泛流行病学在线数据（CDC WONDER）来分析1999年至2022年美国居民（年龄在25 - 64岁之间）中年和青年人群中与心力衰竭及肥胖相关的死亡证明。使用Joinpoint回归分析计算每10万人的年龄调整死亡率（AAMRs）和年度百分比变化（APCs）。
1999年至2022年期间，美国中年和青年人群中共有58,290例死亡归因于肥胖和心力衰竭。总体而言，年龄调整死亡率从1999年的0.72上升了337%，在2021年达到峰值3.15。年龄调整死亡率从1999年的0.72上升了154%，在2019年达到1.83，平均年度百分比变化为4.90（95%可信区间4.57 - 5.33）。与肥胖相关的心力衰竭死亡比例几乎增加了两倍，从1999年的4.5%上升到2021年的峰值12.45%。在整个研究期间，男性和非西班牙裔（NH）黑人的死亡率较高，且差异不断加剧。在美国南部和农村地区也观察到差异加剧的情况。
自1999年以来，美国青年人群中与肥胖相关的心力衰竭死亡率有所上升，且差异不断加剧。男性、非西班牙裔黑人、南部地区和农村地区受到的影响尤为严重。
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