Feng Yingjie, Wang Yajing, Deng Yifan, Li Peifen, Fang Penghua, Zhang Zhenwen
Department of Endocrinology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Department of Endocrinology, Northern Jiangsu People's Hospital, Yangzhou, 225001, China.
Cardiovasc Diabetol. 2025 Aug 13;24(1):332. doi: 10.1186/s12933-025-02863-w.
Diabetic cardiomyopathy (DCM) is a prevalent complication in diabetic patients, and its pathogenic mechanism involves multiple endocrine and metabolic factors, with dyslipidemia playing a pivotal role in the pathogenesis of the disease. Recent studies have highlighted the importance of peptides in energy metabolism and their potential effect on the onset and development of DCM by affecting the function of perivascular adipose tissue (PVAT). The present review aims to examine the effect of these peptides on perivascular adipose tissue and myocardial metabolism during the pathogenesis of DCM, focusing on the role of peptides distributed in perivascular adipose tissue in cardioprotection and their underlying mechanisms of action. In addition, we will explore future research directions and potential clinical applications of these peptides in the treatment of DCM.
糖尿病性心肌病（DCM）是糖尿病患者中常见的并发症，其发病机制涉及多种内分泌和代谢因素，其中血脂异常在该疾病的发病过程中起关键作用。最近的研究强调了肽在能量代谢中的重要性，以及它们通过影响血管周围脂肪组织（PVAT）的功能对DCM发病和发展的潜在影响。本综述旨在研究这些肽在DCM发病过程中对血管周围脂肪组织和心肌代谢的影响，重点关注分布于血管周围脂肪组织中的肽在心脏保护中的作用及其潜在作用机制。此外，我们还将探讨这些肽在DCM治疗中的未来研究方向和潜在临床应用。
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