Hostiuc Sorin, Negoi Ionut, Costescu Mihnea, Siserman Costel
Department of Legal Medicine and Bioethics, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Surgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Int J Mol Sci. 2025 Jul 25;26(15):7184. doi: 10.3390/ijms26157184.
Bone tissue is one of the most remarkable examples of biological plasticity within the human body, with a high regenerative capacity and adaptation following traumatic injuries. This process is conducted through a series of complex and interlinked molecular mechanisms, which will be summarized in this study. The temporal progression of bone healing follows relatively predictable phases, characterized by variation in the concentration and/or activity of biomolecules such as BMP, VEGF, MMPs. The molecular understanding of bone plasticity and regeneration has potentially significant implications in forensic sciences. They were not extensively studied and implemented in practical, forensic environments, mainly due to their high costs and limited availability. However, they have potential uses in areas, such as the interpretation of skeletal trauma, the estimation of the post-traumatic intervals, the postmortem interval, or the differentiation between ante-, peri-, and postmortem injuries to the bone.
骨组织是人体内生物可塑性最显著的例子之一，具有很高的再生能力，能在创伤后进行适应性修复。这个过程是通过一系列复杂且相互关联的分子机制来完成的，本研究将对这些机制进行总结。骨愈合的时间进程遵循相对可预测的阶段，其特征是生物分子（如骨形态发生蛋白、血管内皮生长因子、基质金属蛋白酶）的浓度和/或活性发生变化。对骨可塑性和再生的分子理解在法医学中具有潜在的重大意义。它们在实际的法医环境中尚未得到广泛研究和应用，主要是因为成本高昂且可用性有限。然而，它们在诸如骨骼创伤的解读、创伤后间隔时间的估计、死后间隔时间的估计，或区分骨的生前、伤时和死后损伤等领域具有潜在用途。
