Jhelum Hina, Bender Martin, Reichart Bruno, Abicht Jan-Michael, Längin Matthias, Kaufer Benedikt B, Denner Joachim
Institute of Virology, Free University Berlin, 14163 Berlin, Germany.
Department of Anaesthesiology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.
Int J Mol Sci. 2025 Jul 30;26(15):7378. doi: 10.3390/ijms26157378.
Porcine lymphotropic herpesviruses -1, -2, and -3 (PLHV-1, PLHV-2, and PLHV-3) are gammaherpesviruses that are widespread in pigs. These viruses are closely related to the human pathogens Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV), both of which are known to cause severe diseases in humans. To date, however, no definitive association has been established between PLHVs and any disease in pigs. With the growing interest in xenotransplantation as a means to address the shortage of human organs for transplantation, the safety of using pig-derived cells, tissues, and organs is under intense investigation. In preclinical trials involving pig-to-nonhuman primate xenotransplantation, another porcine herpesvirus-porcine cytomegalovirus, a porcine roseolovirus (PCMV/PRV)-was shown to be transmissible and significantly reduced the survival time of the xenotransplants. In the present study, we examined donor pigs and their respective baboon recipients, all of which were part of preclinical pig heart xenotransplantation studies, for the presence of PLHV. PLHV-1, PLHV-2, and PLHV-3 were detected in nearly all donor pigs; however, no evidence of PLHV transmission to the baboon recipients was observed.
猪嗜淋巴细胞疱疹病毒-1、-2和-3（PLHV-1、PLHV-2和PLHV-3）是广泛存在于猪体内的γ疱疹病毒。这些病毒与人类病原体爱泼斯坦-巴尔病毒（EBV）和卡波西肉瘤相关疱疹病毒（KSHV）密切相关，已知这两种病毒都会在人类中引发严重疾病。然而，迄今为止，尚未确定PLHV与猪的任何疾病之间存在明确关联。随着人们对异种移植作为解决人体移植器官短缺手段的兴趣日益浓厚，使用猪源细胞、组织和器官的安全性正在受到深入研究。在涉及猪到非人灵长类动物异种移植的临床前试验中，另一种猪疱疹病毒——猪巨细胞病毒，一种猪玫瑰疹病毒（PCMV/PRV）——被证明具有传染性，并显著缩短了异种移植的存活时间。在本研究中，我们检查了供体猪及其各自的狒狒受体，它们都是临床前猪心脏异种移植研究的一部分，以检测PLHV的存在。几乎在所有供体猪中都检测到了PLHV-1、PLHV-2和PLHV-3；然而，未观察到PLHV传播给狒狒受体的证据。
