Teoli Miriam, Caviglia Martina, Rega Federica, Barbieri Luca, Ardigò Marco, Mandel Victor Desmond
Porphyria and Rare Diseases Unit, San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy.
Dermatologic Unit, Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, La Sapienza University of Rome, 00185 Rome, Italy.
J Clin Med. 2025 Jul 29;14(15):5338. doi: 10.3390/jcm14155338.
: Lymphomatoid papulosis (LyP) is a primary cutaneous CD30-positive T-cell lymphoproliferative disorder presenting with self-healing erythematous papulonodular lesions that may ulcerate and scar. Treatment varies by lesion extent, location, and severity. : We describe a 57-year-old man with acral LyP successfully treated with chlormethine gel (CG). The patient experienced impaired second finger mobility for over 3 months due to an ulcerated nodular mass. After 3 months of CG treatment, complete remission, symptom resolution, and full joint recovery were achieved. Six months post-treatment, the patient remained in remission. : This case underscores the effectiveness of CG in achieving sustained remission in acral LyP, suggesting its potential as a treatment option for this rare condition.
淋巴瘤样丘疹病（LyP）是一种原发性皮肤CD30阳性T细胞淋巴增殖性疾病，表现为可发生溃疡和瘢痕形成的自愈性红斑丘疹结节性损害。治疗方法因损害范围、部位和严重程度而异。我们描述了一名57岁患有肢端LyP的男性患者，其通过氮芥凝胶（CG）成功治愈。由于溃疡性结节肿块，该患者的示指活动受限超过3个月。经过3个月的CG治疗，实现了完全缓解、症状消退和关节功能完全恢复。治疗后6个月，患者仍处于缓解状态。该病例强调了CG在实现肢端LyP持续缓解方面的有效性，表明其作为这种罕见疾病治疗选择的潜力。
