Lenhart Lukas, Gander Manuela, Steiger Ruth, Dabkowska-Mika Agnieszka, Galijasevic Malik, Mangesius Stephanie, Fuchs Martin, Sevecke Kathrin, Gizewski Elke R
Department of Radiology, Medical University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
Neuroimaging Research Core Facility, Medical University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
J Clin Med. 2025 Aug 1;14(15):5438. doi: 10.3390/jcm14155438.
: Comorbid personality disorders (PDs) in patients with anorexia nervosa (AN) are associated with increased psychopathology, higher suicide risk, and poorer treatment response and outcomes. This study aimed to examine associations between gray matter (GM) volume and PDs in female adolescents with AN before and after short-term psychotherapeutic and nutritional therapy. : Eighteen female adolescents with acute AN, mean age 15.9 years, underwent 3T magnetic resonance imaging before and after weight restoration. The average interval between scans was 2.6 months. Structural brain changes were analyzed using voxel-based morphometry. PDs were assessed using the Structured Clinical Interview for DSM-IV Axis II Disorders (SCID II) and the Assessment of Identity Development Questionnaire. : SCID-II total scores showed significant positive associations with GM volume in the mid-cingulate cortex at both time points and in the left superior parietal-occipital lobule at baseline. The histrionic subscale correlated with GM volume in the thalamus bilaterally and the left superior parietal-occipital lobule in both assessments, as well as with the mid-cingulate cortex at follow-up. Borderline and antisocial subscales were associated with GM volume in the thalamus bilaterally at baseline and in the right mid-cingulate cortex at follow-up. : PDs in female adolescent patients with AN may be specifically related to GM alterations in the thalamus, cingulate, and parieto-occipital regions, which are present during acute illness and persist after weight restoration therapy.
神经性厌食症（AN）患者的共病性人格障碍（PDs）与精神病理学增加、自杀风险升高以及治疗反应和结果较差有关。本研究旨在探讨短期心理治疗和营养治疗前后，患有AN的女性青少年的灰质（GM）体积与PDs之间的关联。18名患有急性AN的女性青少年，平均年龄15.9岁，在体重恢复前后接受了3T磁共振成像检查。两次扫描的平均间隔时间为2.6个月。使用基于体素的形态计量学分析大脑结构变化。使用《精神疾病诊断与统计手册》第四版轴II障碍的结构化临床访谈（SCID II）和身份发展评估问卷对PDs进行评估。SCID-II总分在两个时间点均与扣带回中部的GM体积以及基线时左侧顶上枕叶的GM体积呈显著正相关。在两次评估中，表演型分量表均与双侧丘脑以及左侧顶上枕叶的GM体积相关，并且在随访时与扣带回中部相关。边缘型和反社会型分量表在基线时与双侧丘脑的GM体积相关，在随访时与右侧扣带回中部的GM体积相关。患有AN的女性青少年患者的PDs可能与丘脑、扣带回和顶枕叶区域的GM改变特别相关，这些改变在急性疾病期间存在，并在体重恢复治疗后持续存在。
