Xu Jing, Dong Xinning, Yuan Mu, Chen Xin, Shu Haifeng, Yu Sixun
Department of Neurosurgery, Western Theater General Hospital, Chengdu, China.
College of Medicine, Southwest Jiaotong University, Chengdu, China.
Front Neurol. 2025 Jul 30;16:1635441. doi: 10.3389/fneur.2025.1635441. eCollection 2025.
Ferroptosis is a distinctive form of regulated cell death that is closely associated with various neurodegenerative disorders. In recent years, an increasing number of studies have demonstrated the crucial role of ferroptosis in the development and progression of epilepsy. Firstly, this article will review the existing research on the specific biological mechanism of ferroptosis in nerve injury, particularly in epilepsy, encompassing iron metabolism disorders and alterations in the expression of ferroptosis-related proteins. Secondly, with regards to treatment, this article will explore the application of ferroptosis inhibitors in antiepileptic therapy and their potential therapeutic effects. Additionally, it will focus on investigating the interaction between ferroptosis and existing antiepileptic drugs as well as the potential impact of strategies regulating ferroptosis on epilepsy treatment. Finally, we will evaluate both the progress made and limitations encountered in current research while proposing possible future directions for further exploration at the intersection of ferroptosis and epilepsy fields. These studies not only contribute to a better understanding of epileptic pathological mechanisms but also hold promise for providing novel insights and strategies for treating epilepsy.
铁死亡是一种独特的程序性细胞死亡形式，与多种神经退行性疾病密切相关。近年来，越来越多的研究表明铁死亡在癫痫的发生和发展中起关键作用。首先，本文将综述关于铁死亡在神经损伤，特别是癫痫中具体生物学机制的现有研究，包括铁代谢紊乱和铁死亡相关蛋白表达的改变。其次，关于治疗方面，本文将探讨铁死亡抑制剂在抗癫痫治疗中的应用及其潜在治疗效果。此外，将重点研究铁死亡与现有抗癫痫药物之间的相互作用以及调节铁死亡的策略对癫痫治疗的潜在影响。最后，我们将评估当前研究取得的进展和遇到的局限性，同时提出在铁死亡和癫痫领域交叉点进一步探索的可能未来方向。这些研究不仅有助于更好地理解癫痫的病理机制，也有望为癫痫治疗提供新的见解和策略。
