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Roux-en-Y胃旁路术后慢性吉兰-巴雷综合征与难治性腹泻:一项9年的纵向病例报告

Chronic Guillain-Barré syndrome and refractory diarrhea after RYGB: a 9-year longitudinal case report.

作者信息

Yanzhang Liu, Xiangwen Zhao, Hui Wang, Jinfeng Ji, Shengli Shi

机构信息

Department of Bariatric and Metabolic Surgery, Xiaolan People's Hospital of Zhongshan, No. 65, Jucheng Avenue, Xiaolan Town, Zhongshan, Guangdong 528415, China.

Department of Neurology, Xiaolan People's Hospital of Zhongshan, No. 65, Jucheng Avenue, Xiaolan Town, Zhongshan, Guangdong 528415, China.

出版信息

J Surg Case Rep. 2025 Aug 13;2025(8):rjaf596. doi: 10.1093/jscr/rjaf596. eCollection 2025 Aug.

Abstract

We present a 46-year-old male who developed chronic Guillain-Barré syndrome and refractory diarrhea after undergoing Roux-en-Y gastric bypass, with progressive neurological deterioration and 34.9% total weight loss over 9 years. Serial evaluations demonstrated severe deficiencies include vitamin D, calcium, iron and other nutritions, accompanied by evidence of autoimmune dysregulation. The patient's condition progressed to require partial parenteral nutrition due to worsening neurological and gastrointestinal dysfunction. This case highlights the critical need for ongoing nutritional monitoring after bariatric surgery and suggests that persistent micronutrient deficiencies may contribute to sustained immune dysfunction, potentially triggering chronic autoimmune neurological disorders in susceptible individuals.

摘要

我们报告一名46岁男性,在接受Roux-en-Y胃旁路手术后出现慢性吉兰-巴雷综合征和难治性腹泻,在9年中神经功能逐渐恶化,体重减轻了34.9%。系列评估显示严重缺乏维生素D、钙、铁和其他营养素,伴有自身免疫调节异常的证据。由于神经和胃肠功能障碍恶化,患者病情进展至需要部分胃肠外营养。该病例突出了减肥手术后持续营养监测的迫切需求,并表明持续的微量营养素缺乏可能导致持续的免疫功能障碍,有可能在易感个体中引发慢性自身免疫性神经疾病。

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本文引用的文献

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Guillain-Barré syndrome: a comprehensive review.格林-巴利综合征:全面综述。
Eur J Neurol. 2024 Aug;31(8):e16365. doi: 10.1111/ene.16365. Epub 2024 May 30.
4
Guillain-Barré syndrome after surgery: a literature review.手术后吉兰-巴雷综合征:文献综述
Front Neurol. 2024 Apr 4;15:1368706. doi: 10.3389/fneur.2024.1368706. eCollection 2024.
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Micronutrients deficiences in patients after bariatric surgery.肥胖症患者手术后的微量营养素缺乏症。
Eur J Nutr. 2022 Feb;61(1):55-67. doi: 10.1007/s00394-021-02619-8. Epub 2021 Jul 23.
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Brain. 2018 Oct 1;141(10):2866-2877. doi: 10.1093/brain/awy232.
10
Diarrhea after bariatric procedures: Diagnosis and therapy.减肥手术后的腹泻:诊断与治疗
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