人类癌症中的METTL1：对其功能、机制及治疗价值的认识
METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value.
作者信息
Zhang Xinyu, Chen Yuan, Li Min, Zhou Xiaomeng, Song Qingcui
机构信息
School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Department of Precision Biomedical Key Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, China.
出版信息
Oncol Rev. 2025 Jul 30;19:1637372. doi: 10.3389/or.2025.1637372. eCollection 2025.
Methyltransferase-like 1 (METTL1) is a methyltransferase that modulates the RNA methylation process and has been increasingly investigated in cancer research over the past decade. The review aims to summarize the diverse roles of METTL1 in various cancers, focusing on the mechanisms underlying tumorigenesis, progression, and metastasis. Furthermore, the therapeutic value and targeting strategies for METTL1 are also discussed to provide the foundation for further development of METTL1-targeted therapies. The article integrates recent research findings to highlight significant discoveries regarding METTL1, emphasizing its potential as a therapeutic target in cancer treatment.
甲基转移酶样蛋白1（METTL1）是一种调节RNA甲基化过程的甲基转移酶，在过去十年中，它在癌症研究中受到了越来越多的关注。这篇综述旨在总结METTL1在各种癌症中的不同作用，重点关注肿瘤发生、进展和转移的潜在机制。此外，还讨论了METTL1的治疗价值和靶向策略，为进一步开发针对METTL1的治疗方法奠定基础。本文整合了最近的研究结果，以突出关于METTL1的重大发现，强调其作为癌症治疗中治疗靶点的潜力。
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