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基于最近邻匹配分析技术估算乌干达五岁以下儿童的疟疾风险。

Estimating the under-five malaria risk in Uganda based on the nearest neighbour matched analysis technique.

作者信息

Natuhamya Charles

机构信息

Makerere University, School of Public Health.

出版信息

Afr Health Sci. 2024 Jun;24(2):173-180. doi: 10.4314/ahs.v24i2.20.

Abstract

INTRODUCTION

Malaria still remains a global burden especially in the under-five despite efforts made towards reducing it. The most recommended vector control methods are; use of insecticide treated nets (ITNs) or long lasting insecticide nets (LLINs) and use of indoor residual spraying (IRS). However, these innovations may not have the same effect on malaria risk in the under-five. This study therefore aimed at assessing; the effect of ITNs/LLINs on malaria risk, the effect of IRS on malaria risk, and the effect of ITNs/LLINs on IRS, using nearest neighbours matched analysis.

METHODS

Nearest neighbour matched analysis was used to match the treated and control units by taking each treated unit and searching for the control unit with the nearest neighbours without replacement.

RESULTS

The results revealed a significant and negative effect of ITNs/LLINs and IRS on malaria risk [ATET=-0.05; 95% CI= -0.07 - -0.02] and [ATET=-0.12; 95% CI= -0.15 - -0.09] respectively. It also found a significant and positive effect of ITNs/LLINs on IRS [ATET=0.03; 95% CI= 0.01 - 0.05].

CONCLUSIONS

The implementation of policies and programs towards effective use of ITN/LLIN and IRS can reduce the burden of under-five malaria in Uganda.

摘要

引言

尽管为减少疟疾做出了努力,但疟疾仍然是一个全球负担,尤其是对五岁以下儿童而言。最推荐的病媒控制方法是:使用经杀虫剂处理的蚊帐(ITN)或长效杀虫剂蚊帐(LLIN)以及进行室内滞留喷洒(IRS)。然而,这些创新措施对五岁以下儿童的疟疾风险可能没有相同的效果。因此,本研究旨在评估:ITN/LLIN对疟疾风险的影响、IRS对疟疾风险的影响以及ITN/LLIN对IRS的影响,采用最近邻匹配分析。

方法

采用最近邻匹配分析,通过选取每个处理单元并在无放回的情况下寻找最近邻的对照单元来匹配处理单元和对照单元。

结果

结果显示,ITN/LLIN和IRS对疟疾风险分别有显著的负面影响[平均处理效应(ATET)=-0.05;95%置信区间(CI)=-0.07至-0.02]和[ATET=-0.12;95%CI=-0.15至-0.09]。研究还发现ITN/LLIN对IRS有显著的正面影响[ATET=0.03;95%CI=0.01至0.05]。

结论

实施有效使用ITN/LLIN和IRS的政策和计划可以减轻乌干达五岁以下儿童的疟疾负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e665/12341157/c3e30097a9ba/AFHS2402-0173Fig1.jpg

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