Lazar Andrada-Luciana, Romana Vulturar Cleopatra, Sitar-Tăut Adela-Viviana, Suharoschi Ramona, Orășan Olga Hilda, Chiș Adina Ancuța, Fodor Adriana, Tiperciuc Brîndușa, Login Cezar, Cozma Angela
Internal Medicine Department 4th Medical Clinic "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca Romania.
Dermatology Department Integrated Ambulatory - Infectious Diseases Clinical Hospital Cluj-Napoca Romania.
Health Sci Rep. 2025 Aug 13;8(8):e71128. doi: 10.1002/hsr2.71128. eCollection 2025 Aug.
Psoriasis is an immune-mediated disease affecting primarily the skin and joints, but which also has systemic implications. There are assumptions about a common genetic background between psoriasis and cardiovascular diseases. This narrative review aims to provide an overview of the existing data regarding the IL-23 rs2066808, IL-23R rs2201841, IL-17RA rs4819554, and IL-17A rs2275913 polymorphisms and their link to psoriasis and cardiovascular diseases.
PubMed, Web of Science, Scopus, and "SNPedia" searches were conducted to identify the relevant studies between 2007 and 2025 that investigated the association between psoriasis, cardiovascular diseases, and the IL-23 rs2066808, IL-23R rs2201841, IL-17RA rs4819554, and IL17A rs2275913 polymorphisms.
The existing data are conflicting. The polymorphisms could be implicated in psoriasis onset, disease susceptibility, and treatment response. Some of them are also linked to coronary artery disease. Contradictory data could result from the heterogeneity of the population included in the studies and the laboratory techniques used for polymorphism determination.
The interplay between IL-17, IL-23, and genetic polymorphisms illustrates a complex landscape in psoriasis and its associated comorbidities. More standardized case-control studies are needed to confirm this hypothesis. Moreover, extensive studies in diverse populations would be important to clarify these relationships and the potential implications for treatment and management.
银屑病是一种免疫介导的疾病，主要影响皮肤和关节，但也有全身影响。有观点认为银屑病与心血管疾病存在共同的遗传背景。本叙述性综述旨在概述关于白细胞介素-23（IL-23）rs2066808、白细胞介素-23受体（IL-23R）rs2201841、白细胞介素-17A受体（IL-17RA）rs4819554和白细胞介素-17A（IL-17A）rs2275913基因多态性及其与银屑病和心血管疾病关联的现有数据。
在PubMed、科学网、Scopus和“SNPedia”中进行检索，以识别2007年至2025年间研究银屑病、心血管疾病与IL-23 rs2066808、IL-23R rs2201841、IL-17RA rs4819554和IL-17A rs2275913基因多态性之间关联的相关研究。
现有数据相互矛盾。这些基因多态性可能与银屑病的发病、疾病易感性和治疗反应有关。其中一些还与冠状动脉疾病有关。矛盾的数据可能源于研究中纳入人群的异质性以及用于基因多态性测定的实验室技术。
IL-17、IL-23与基因多态性之间的相互作用在银屑病及其相关合并症中呈现出复杂的情况。需要更多标准化的病例对照研究来证实这一假设。此外，在不同人群中进行广泛研究对于阐明这些关系以及对治疗和管理的潜在影响至关重要。
