Buyan R D, Schroeder R L, Perkins W E
Res Commun Chem Pathol Pharmacol. 1985 Oct;50(1):135-8.
Metoclopramide has gained acceptance as an effective drug for the control of nausea and vomiting in cancer patients receiving cisplatin chemotherapy. In addition to its emetogenic side effects, cisplatin is known to be nephrotoxic. This animal study was undertaken to determine if the severity of cisplatin-induced nephrotoxicity is altered by the coadministration of metoclopramide. Female F-344 rats received subcutaneous saline or metoclopramide 30 min before and 120 min after intravenous administration of saline or cisplatin. Animals were sacrificed on the 5th day following treatment. Decreases in body weight, elevations in serum urea nitrogen and histopathological changes were of similar magnitude in all cisplatin treated groups regardless of concomitant metoclopramide administration. Saline dosed control animals did not exhibit these changes. It is concluded that the coadministration of metoclopramide did not significantly alter the nephrotoxic effects of cisplatin in this experiment.
甲氧氯普胺已被公认为是一种有效的药物，可用于控制接受顺铂化疗的癌症患者的恶心和呕吐。除了具有致吐副作用外，顺铂还已知具有肾毒性。进行这项动物研究是为了确定同时给予甲氧氯普胺是否会改变顺铂诱导的肾毒性的严重程度。雌性F-344大鼠在静脉注射生理盐水或顺铂前30分钟和后120分钟接受皮下注射生理盐水或甲氧氯普胺。在治疗后的第5天处死动物。无论是否同时给予甲氧氯普胺，所有接受顺铂治疗的组中体重减轻、血清尿素氮升高和组织病理学变化的程度相似。给予生理盐水的对照动物未出现这些变化。得出的结论是，在本实验中，同时给予甲氧氯普胺并未显著改变顺铂的肾毒性作用。
