Schumacher Katja, de la Cuesta Manuela, Marin-Cuartas Mateo, Aydin Muhammed Ikbal, Meier Sabine, Dähnert Ingo, Borger Michael A, Kostelka Martin, Vollroth Marcel
University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany.
Department of Pediatric Cardiology, Leipzig Heart Center, Leipzig, Germany.
Ann Pediatr Cardiol. 2025 Jan-Feb;18(1):13-18. doi: 10.4103/apc.apc_249_24. Epub 2025 Jul 14.
Aortic coarctation (CoA) accounts for 5%-8% of congenital heart defects, and patients' symptoms can range from neonatal shock to hypertension in adolescence or even adulthood. While surgical repair is the gold standard, catheter-based therapies are increasingly utilized. Despite advancements, complications, and recurrence rates necessitating re-intervention remain concerns.
We analyzed the postoperative outcomes and long-term intervention rates for pediatric patients undergoing extended end-to-end CoA repair without cardiopulmonary bypass between October 2002 and January 2024 at the Leipzig Heart Center. Data were prospectively collected and retrospectively analyzed.
Among 168 patients, the median age at surgery was 11 days (interquartile range [IQR] 6-26). There was no early mortality. Median intensive care unit stay was 4 days (IQR 3-5), and hospital stay was 9 days (IQR 7-12). Early re-intervention during the same hospital stay was required in 3% due to re-coarctation. Median follow-up was 33 months (IQR 7 months-8 years). Long-term survival at 1, 5, 10, and 14 years was 100%, 98.9%, 98.9%, and 98.9%, respectively. Freedom from catheter-based intervention was 74.3%, 70.1%, 67.9%, and 64.8% at the same intervals.
Extended end-to-end anastomosis for CoA repair in children yields excellent survival and acceptable long-term outcomes, though re-intervention remains a consideration.
主动脉缩窄(CoA)占先天性心脏病的5%-8%,患者症状从新生儿休克到青春期甚至成年期的高血压不等。虽然手术修复是金标准,但基于导管的治疗方法使用越来越多。尽管取得了进展,但并发症和需要再次干预的复发率仍然令人担忧。
我们分析了2002年10月至2024年1月在莱比锡心脏中心接受非体外循环下扩大端端CoA修复的儿科患者的术后结果和长期干预率。数据进行前瞻性收集和回顾性分析。
168例患者中,手术时的中位年龄为11天(四分位间距[IQR]6-26)。无早期死亡。重症监护病房中位住院时间为4天(IQR 3-5),住院时间为9天(IQR 7-12)。3%的患者因再缩窄在同一住院期间需要早期再次干预。中位随访时间为33个月(IQR 7个月-8年)。1年、5年、10年和14年的长期生存率分别为100%、98.9%、98.9%和98.9%。在相同时间间隔内,无需基于导管干预的比例分别为74.3%、70.1%、67.9%和64.8%。
儿童CoA修复采用扩大端端吻合术可获得优异的生存率和可接受的长期结果,不过再次干预仍是一个需要考虑的问题。