代谢手术与常规治疗对肥胖合并2型糖尿病患者死亡率的影响:一项系统评价和荟萃分析。

Metabolic surgery versus usual care effects on mortality among patients with obesity and type 2 diabetes: A systematic review and meta-analysis.

作者信息

Albalawi Ibrahim Altedlawi, Mirghani Hyder

机构信息

Department of Surgery, Faculty of Medicine, University of Tabuk, Saudi Arabia.

Department of Internal Medicine, Faculty of Medicine, University of Tabuk, Saudi Arabia.

出版信息

J Res Med Sci. 2025 Jul 24;30:41. doi: 10.4103/jrms.jrms_360_24. eCollection 2025.

Abstract

Although bariatric surgery is recommended for obesity treatment, there is an increasing trend toward comorbidity-related indications. The effects of bariatric surgery on mortality are inconsistent. This meta-analysis aimed to assess metabolic surgery versus usual care on mortality among patients with obesity and type 2 diabetes. we searched six databases for articles comparing bariatric surgery with usual care in terms of mortality. The terms used were bariatric surgery, metabolic surgery, lifestyles, usual care, gastric banding, bypass surgery, biliopancreatic diversion, gastric bypass, sleeve gastrectomy, and Roux-en-Y gastric bypass. The search engine was set for articles from inception up to June 2024. Out of the 1960 studies retrieved, 1810 were retained after the removal of duplication; from them, 75 full texts were eligible, and only 26 studies were included in the final meta-analysis. The study included 866,159 patients (167,152 patients who underwent bariatric surgery and 699,007 usual care patients) and 91,211 deaths. Mortality was lower among patients with bariatric surgery compared to usual care (3.1% vs. 12.6%), odds ratio = 0.43, 95% confidence interval (CI), 0.32-0.58, Chi-square = 1638.20, and < 0.001, for heterogeneity = 99%, and the standard difference = 24. Mortality was higher in bariatric surgery in subgroup meta-analysis on patients with type 2 diabetes (2.6% versus 2.0%), odds ratio, 0.63, 95% CI, 0.42-0.95, Chi-square = 101.04, and = 0.03 for heterogeneity = 95%, and the standard difference = 5. Bariatric surgery was associated with lower mortality in patients with obesity compared to usual care, but higher mortality in subgroup meta-analysis in type 2 diabetes. Larger, well-controlled trials are needed.

摘要

尽管减重手术被推荐用于肥胖治疗,但与合并症相关的适应症有增加的趋势。减重手术对死亡率的影响并不一致。这项荟萃分析旨在评估代谢手术与常规治疗对肥胖和2型糖尿病患者死亡率的影响。我们在六个数据库中搜索了比较减重手术与常规治疗在死亡率方面的文章。使用的术语有减重手术、代谢手术、生活方式、常规治疗、胃束带术、旁路手术、胆胰转流术、胃旁路手术、袖状胃切除术和Roux-en-Y胃旁路手术。搜索引擎设置为检索从开始到2024年6月的文章。在检索到的1960项研究中,去除重复后保留了1810项;其中75篇全文符合条件,最终的荟萃分析仅纳入了26项研究。该研究纳入了866,159名患者(167,152名接受减重手术的患者和699,007名接受常规治疗的患者)以及91,211例死亡病例。与常规治疗相比,接受减重手术的患者死亡率更低(3.1%对12.6%),比值比 = 0.43,95%置信区间(CI)为0.32 - 0.58,卡方 = 1638.20,P < 0.001,异质性I² = 99%,标准化差异 = 24。在2型糖尿病患者的亚组荟萃分析中,减重手术的死亡率更高(2.6%对2.0%),比值比为 = 0. = 0.63,95% CI为0.42 - 0.95,卡方 = 101.04,P = 0.03,异质性I² = 95%,标准化差异 = 5。与常规治疗相比,减重手术与肥胖患者较低的死亡率相关,但在2型糖尿病的亚组荟萃分析中死亡率更高。需要进行更大规模、严格控制的试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f45b/12352692/9746b87fef38/JRMS-30-41-g001.jpg

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