质粒拷贝数作为细菌致病机制和抗生素耐药性的调节因子。

Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance.

作者信息

Wang Helen, Joffré Enrique

机构信息

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.

出版信息

NPJ Antimicrob Resist. 2025 Aug 18;3(1):72. doi: 10.1038/s44259-025-00145-9.

DOI:10.1038/s44259-025-00145-9

PMID:40826263

Abstract

Plasmid copy number (PCN), the average number of plasmids per bacterial cell, links gene dosage to key traits such as host fitness, virulence, antibiotic resistance and evolutionary potential. Although often viewed as static, PCN is a dynamic, regulated trait responsive to environmental cues and selection pressures. This review examines the regulatory mechanisms controlling PCN and its impact on the trade-offs between bacterial fitness, virulence cost, and antibiotic resistance.

摘要

质粒拷贝数（PCN），即每个细菌细胞中质粒的平均数量，将基因剂量与宿主适应性、毒力、抗生素抗性和进化潜力等关键性状联系起来。尽管质粒拷贝数通常被视为静态的，但它是一个动态的、受调控的性状，对环境线索和选择压力有响应。本文综述了控制质粒拷贝数的调控机制及其对细菌适应性、毒力代价和抗生素抗性之间权衡的影响。