Hu Ke, Ma Ming-Wei, Li Xue-Song, Yang Kai-Wei, Li Hong-Zhen, Li Xiao-Ying, Chen Jia-Yan, Ren Xue-Ying, Shen Qi, Yu Wei, Gao Xian-Shu
Department of Radiation Oncology, Peking University First Hospital, Peking University, Beijing, 100034, China.
Department of Urology, Peking University First Hospital, Peking University, Beijing, 100034, China.
Clin Exp Med. 2025 Aug 19;25(1):296. doi: 10.1007/s10238-025-01770-4.
This study aimed to comprehensively delineate the clinical characteristics, surgical interventions, and evolving trends over the past decade among patients undergoing surgery for renal cell carcinoma (RCC). A retrospective analysis was conducted on the clinical records of 9,110 patients diagnosed with RCC who underwent surgical treatment at Peking University First Hospital between January 2013 and December 2022. Statistical analyses were performed using SPSS 21.0 software. Categorical variables were analyzed using the Chi-square test or Fisher's exact test, as appropriate. Numerical variables were assessed using the t-test or analysis of variance (ANOVA) for normally distributed data, while nonparametric tests were employed for non-normally distributed numerical variables or ordinal data. A p-value of less than 0.05 was considered statistically significant. The study cohort consisted of 6,416 males (70.4%) and 2,694 females (29.6%), with a median age of 55 years. Clear cell renal cell carcinoma (ccRCC) was the most prevalent histological subtype (87.6%), followed by chromophobe renal cell carcinoma (chRCC) (5.1%), papillary renal cell carcinoma (pRCC) (3.7%), and other subtypes (3.6%). Non-ccRCC patients exhibited a significantly higher proportion of advanced T3 + disease staging (19.4% vs. 15%, P < 0.001). Female patients demonstrated higher incidences of both non-ccRCC and special pathology types (P < 0.001), while non-ccRCC and advanced T-stage disease were more common in pediatric patients (P < 0.001) and were more likely to undergo radical nephrectomy (P < 0.001). Over the span of a decade, the demographic characteristics of RCC patients remained relatively stable; however, there was a notable decrease in tumor size over time (P < 0.001). Notably, partial nephrectomy rates surged between 2013 and 2016-reflecting growing acceptance of nephron-sparing techniques-but later balanced with radical nephrectomies as stricter selection criteria emerged, highlighting the dynamic evolution of RCC surgical management. Our study reveals dynamic shifts in RCC management over the past decade, marked by evolving surgical practices and a trend toward smaller tumor sizes at diagnosis, while distinct clinical features in pediatric patients underscore the need for continued refinement of early detection.
本研究旨在全面描述过去十年间接受肾细胞癌(RCC)手术患者的临床特征、手术干预措施及发展趋势。对2013年1月至2022年12月期间在北京大学第一医院接受手术治疗的9110例确诊为RCC患者的临床记录进行回顾性分析。使用SPSS 21.0软件进行统计分析。分类变量根据情况使用卡方检验或Fisher精确检验进行分析。数值变量对于正态分布数据使用t检验或方差分析(ANOVA)进行评估,对于非正态分布的数值变量或有序数据则采用非参数检验。p值小于0.05被认为具有统计学意义。研究队列包括6416例男性(70.4%)和2694例女性(29.6%),中位年龄为55岁。透明细胞肾细胞癌(ccRCC)是最常见的组织学亚型(87.6%),其次是嫌色肾细胞癌(chRCC)(5.1%)、乳头状肾细胞癌(pRCC)(3.7%)和其他亚型(3.6%)。非ccRCC患者中晚期T3+疾病分期的比例显著更高(19.4%对15%,P<0.001)。女性患者中非ccRCC和特殊病理类型的发生率均较高(P<0.001),而在儿科患者中非ccRCC和晚期T分期疾病更为常见(P<0.001),并且更有可能接受根治性肾切除术(P<0.001)。在十年期间,RCC患者的人口统计学特征保持相对稳定;然而,随着时间的推移肿瘤大小显著减小(P<0.001)。值得注意的是,2013年至2016年间部分肾切除术的比例激增——这反映了对保留肾单位技术的接受度不断提高——但随着更严格的选择标准出现,后来与根治性肾切除术达到平衡,突出了RCC手术管理的动态演变。我们的研究揭示了过去十年间RCC管理的动态变化,其特点是手术实践不断演变以及诊断时肿瘤尺寸趋于更小的趋势,而儿科患者独特的临床特征强调了持续完善早期检测的必要性。