Wang Xiaoxuan, Liu Xiaopeng, Hou Jie, Liu Sijun, Yang Shirui, Lei Yulin
Department of Ophthalmology, Binzhou Medical University, Binzhou, Shandong 256603, P.R. China.
Department of Ophthalmology, Jinan Mingshui Eye Hospital, Jinan, Shandong 250200, P.R. China.
Exp Ther Med. 2025 Aug 5;30(4):186. doi: 10.3892/etm.2025.12936. eCollection 2025 Oct.
The present study aimed to investigate the feasibility and design of producing a parallel/concave lenticule using an excimer laser on a convex corneal matrix lenticule . Optical coherence tomography was used to measure the thickness of the corneal stromal lenticules. Lenticules were cut using an excimer laser. The lenticules were divided into three groups: 1:1, 1:1.5 and 1:2 cuttings. After cutting, the lenticule thickness was measured again. Thickness changes in the three groups were compared before and after the cuts. Significant differences were observed among the three groups in central thickness, thickness changes (1.5 mm) and the difference between central thickness and thickness (2 mm from the centre) before and after cutting. However, thickness changes at 2 and 2.5 mm from the centre were not statistically significant. The differences between the central thickness and thickness at 2 mm from the centre after shaping (with interquartile ranges) were as follows: 38 (28, 53.5) µm in Group Ⅰ, 6 (-3,15.5) µm in Group II and -10 (-16.5, -5) µm in Group III. In conclusion, excimer cutting at different proportions affected thickness changes at the centre and 1.5 mm from the centre. Furthermore, it did not affect the thickness change at 2 and 2.5 mm from the centre. The lenticule obtained by a 1:1 cutting ratio was convex and the lenticule formed by a 1:1.5 cutting ratio retained a convex shape. However, the centre was very close to the parallel lenticule. The lenticule obtained using a 1:2 cutting ratio was concave.
本研究旨在探讨在凸角膜基质透镜上使用准分子激光制作平行/凹透镜的可行性及设计。采用光学相干断层扫描测量角膜基质透镜的厚度。使用准分子激光切割透镜。将透镜分为三组：1:1、1:1.5和1:2切割比例。切割后，再次测量透镜厚度。比较三组切割前后的厚度变化。三组在中央厚度、厚度变化（1.5毫米处）以及切割前后中央厚度与距中心2毫米处厚度的差值方面存在显著差异。然而，距中心2毫米和2.5毫米处的厚度变化无统计学意义。塑形后中央厚度与距中心2毫米处厚度的差值（四分位间距）如下：Ⅰ组为38（28，53.5）微米，Ⅱ组为6（-3，15.5）微米，Ⅲ组为-10（-16.5，-5）微米。总之，不同比例的准分子切割影响中心及距中心1.5毫米处的厚度变化。此外，它不影响距中心2毫米和2.5毫米处的厚度变化。1:1切割比例获得的透镜为凸形，1:1.5切割比例形成的透镜保持凸形。然而，其中心非常接近平行透镜。1:2切割比例获得的透镜为凹形。
