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利用食物衍生信号调节生物衰老：系统与精准营养视角

Modulating biological aging with food-derived signals: a systems and precision nutrition perspective.

作者信息

Carlberg Carsten, Blüthner Andreas, Schoeman-Giziakis Irini, Oosting Annemarie, Cocolin Luca

机构信息

Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.

Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

出版信息

NPJ Aging. 2025 Aug 20;11(1):76. doi: 10.1038/s41514-025-00266-5.

DOI:10.1038/s41514-025-00266-5
PMID:40835817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12368197/
Abstract

Lifespan extension has not prevented age-related decline. We propose that diet acts as a molecular modulator of aging, influencing inflammation, the microbiome, and systemic resilience. Biological age markers and AI-powered multi-omics reveal actionable dietary targets, including food-derived signals and Nutrition Dark Matter. We highlight precision nutrition and the EIT Food Healthy Aging Think & Do Tank as pathways to align science, policy, and practice for healthy aging.

摘要

寿命延长并未阻止与年龄相关的衰退。我们提出，饮食作为衰老的分子调节剂，影响炎症、微生物群和全身恢复力。生物年龄标志物和人工智能驱动的多组学揭示了可采取行动的饮食靶点，包括食物衍生信号和营养暗物质。我们强调精准营养以及欧洲创新与技术研究院食品健康老龄化行动小组，将其作为使科学、政策和实践与健康老龄化保持一致的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78f/12368197/4e13bdba7d05/41514_2025_266_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78f/12368197/aced91394018/41514_2025_266_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78f/12368197/4e13bdba7d05/41514_2025_266_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78f/12368197/aced91394018/41514_2025_266_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78f/12368197/4e13bdba7d05/41514_2025_266_Fig2_HTML.jpg

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Modulating biological aging with food-derived signals: a systems and precision nutrition perspective.

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本文引用的文献

[1]
Chemical Complexity of Food and Implications for Therapeutics.

N Engl J Med. 2025-5-8

[2]
Optimal dietary patterns for healthy aging.

Nat Med. 2025-5

[3]
Epigenetic ageing clocks: statistical methods and emerging computational challenges.

Nat Rev Genet. 2025-5

[4]
Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals.

Nat Microbiol. 2025-1

[5]
Circadian clock communication during homeostasis and ageing.

Nat Rev Mol Cell Biol. 2025-4

[6]
Fecal microbiota transplantation, a tool to transfer healthy longevity.

Ageing Res Rev. 2025-1

[7]
Lessons Learned From Blue Zones, Lifestyle Medicine Pillars and Beyond: An Update on the Contributions of Behavior and Genetics to Wellbeing and Longevity.

Am J Lifestyle Med. 2022-8-20

[8]
Challenges and recommendations for the translation of biomarkers of aging.

Nat Aging. 2024-10

[9]
Nonlinear dynamics of multi-omics profiles during human aging.

Nat Aging. 2024-11

[10]
Five years of change in adult twins: longitudinal changes of genetic and environmental influence on epigenetic clocks.

BMC Med. 2024-7-10

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