Wang Yiqiao, Chen Yuncan, Xu Shimin, Wu Xunyi
Department of Neurology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
National Center for Neurological Disorders, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Acta Epileptol. 2025 Aug 21;7(1):41. doi: 10.1186/s42494-025-00234-2.
Translocator protein positron emission tomography (TSPO-PET) is a novel imaging modality that leverages the high expression of TSPO in activated microglia and other cells within seizure foci. It has been increasingly applied in the preoperative evaluation of drug-resistant epilepsy (DRE) to aid in the localization of these foci. With advances in tracer development, TSPO-PET has achieved higher signal-to-noise ratios and broader clinical utility. Clinical studies indicate that TSPO-PET yields significantly higher positive detection rates for seizure foci compared to magnetic resonance imaging and fluorodeoxyglucose positron emission tomography. This review summarizes recent progress in TSPO-PET radiotracer technology, its mechanism of action, and its clinical applications for managing DRE.
转位蛋白正电子发射断层扫描（TSPO-PET）是一种新型成像方式，它利用癫痫病灶内活化小胶质细胞和其他细胞中TSPO的高表达。它已越来越多地应用于药物难治性癫痫（DRE）的术前评估，以辅助这些病灶的定位。随着示踪剂开发的进展，TSPO-PET已实现更高的信噪比和更广泛的临床应用。临床研究表明，与磁共振成像和氟脱氧葡萄糖正电子发射断层扫描相比，TSPO-PET对癫痫病灶的阳性检出率显著更高。本综述总结了TSPO-PET放射性示踪剂技术的最新进展、其作用机制及其在管理DRE中的临床应用。
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