肌肉相关疾病与衰老的潜在机制：对病理生理学和治疗策略的见解

Mechanisms Underlying Muscle-Related Diseases and Aging: Insights into Pathophysiology and Therapeutic Strategies.

作者信息

Fan Jialin, Khanzada Zara, Xu Yunpeng

机构信息

School of Arts and Sciences, Chemistry and Chemical Biology Cancer Institute of New Jersey (CINJ), Director's Office Cancer Institute of New Jersey (CINJ), Rutgers University, New Brunswick, NJ 08901, USA.

Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.

出版信息

Muscles. 2025 Jul 31;4(3):26. doi: 10.3390/muscles4030026.

DOI:10.3390/muscles4030026

PMID:40843913

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12371960/

Abstract

Skeletal muscle aging and related diseases are characterized by progressive loss of muscle mass, strength, and metabolic function. Central to these processes is mitochondrial dysfunction, which impairs energy metabolism, redox homeostasis, and proteostasis. In addition, non-mitochondrial factors such as muscle stem cell exhaustion, neuromuscular junction remodeling, and chronic inflammation also contribute significantly to muscle degeneration. This review integrates recent advances in understanding mitochondrial and non-mitochondrial mechanisms underlying muscle aging and disease. Additionally, we discuss emerging therapeutic approaches targeting these pathways to preserve muscle health and promote healthy aging.

摘要

骨骼肌衰老及相关疾病的特征是肌肉质量、力量和代谢功能逐渐丧失。这些过程的核心是线粒体功能障碍，它会损害能量代谢、氧化还原稳态和蛋白质稳态。此外，肌肉干细胞耗竭、神经肌肉接头重塑和慢性炎症等非线粒体因素也对肌肉退化有显著影响。本综述整合了在理解肌肉衰老和疾病背后的线粒体和非线粒体机制方面的最新进展。此外，我们还讨论了针对这些途径的新兴治疗方法，以维护肌肉健康并促进健康衰老。